Collagen derived Gly-Pro-type DPP-IV inhibitory peptides: Structure-activity relationship, inhibition kinetics and inhibition mechanism

Q Xu, L Zheng, M Huang, M Zhao - Food chemistry, 2024 - Elsevier
Our previous study has demonstrated that both the amino acid at N3 position and peptide
length affected the DPP-IV inhibitory activity of Gly-Pro-type peptides. To further elucidate …

Virtual screening strategy for anti-DPP-IV natural flavonoid derivatives based on machine learning

G Lu, F Pan, X Li, Z Zhu, L Zhao, Y Wu… - Journal of …, 2024 - Taylor & Francis
Flavonoids, especially their inhibitory effect on DPP-IV activity, have been widely recognized
for their antidiabetic effects. However, the variety of natural flavonoid derivatives is very rich …

[HTML][HTML] In silico analysis of novel dipeptidyl peptidase-IV inhibitory peptides released from Macadamia integrifolia antimicrobial protein 2 (MiAMP2) and the possible …

L Zhao, M Zhang, F Pan, J Li, R Dou, X Wang… - Current research in food …, 2021 - Elsevier
The aim of the present study was to screen novel dipeptidyl peptidase IV (DPP-IV) inhibitory
peptides from Macadamia integrifolia antimicrobial protein 2 (MiAMP2) and evaluate the …

Identification, screening, and comprehensive evaluation of novel DPP-IV inhibitory peptides from the Tilapia skin gelatin hydrolysate produced using ginger protease

W Liu, X Wang, W Yang, X Li, D Qi, H Chen, H Liu… - Biomolecules, 2022 - mdpi.com
Purpose: Inhibition of dipeptidyl peptidase-IV (DPP-IV) is an effective therapy for treating
type II diabetes (T2D) that has been widely applied in clinical practice. We aimed to evaluate …

Integration of Deep Learning and Sequential Metabolism to Rapidly Screen Dipeptidyl Peptidase (DPP)-IV Inhibitors from Gardenia jasminoides Ellis

H Liu, S Yu, X Li, X Wang, D Qi, F Pan, X Chai, Q Wang… - Molecules, 2023 - mdpi.com
Traditional Chinese medicine (TCM) possesses unique advantages in the management of
blood glucose and lipids. However, there is still a significant gap in the exploration of its …

Molecular Mechanistic Insights into Dipeptidyl Peptidase-IV Inhibitory Peptides to Decipher the Structural Basis of Activity

C Wang, L Zheng, CC Udenigwe, L Lin… - Journal of Agricultural …, 2024 - ACS Publications
Dipeptidyl peptidase-IV (DPP-IV) inhibiting peptides have attracted increased attention
because of their possible beneficial effects on glycemic homeostasis. However, the …

[HTML][HTML] Identifying novel SMYD3 interactors on the trail of cancer hallmarks

C Fasano, ML Signorile, K De Marco, G Forte… - Computational and …, 2022 - Elsevier
SMYD3 overexpression in several human cancers highlights its crucial role in
carcinogenesis. Nonetheless, SMYD3 specific activity in cancer development and …

A Quinoa Protein Hydrolysate Fractionated by Electrodialysis with Ultrafiltration Membranes Improves Maternal and Fetal Outcomes in a Mouse Model of Gestational …

D Busso, A González, N Santander… - Molecular Nutrition & …, 2023 - Wiley Online Library
Scope Quinoa intake exerts hypoglycemic and hypolipidemic effects in animals and
humans. Although peptides from quinoa inhibit key enzymes involved in glucose …

刺参胶原蛋白源二肽基肽酶抑制肽虚拟筛选及分子对接研究.

曲亭菲, 赵前程, 李双双, 韩明哲… - Journal of Food …, 2023 - search.ebscohost.com
目的采用生物信息学和分子对接方法筛选仿刺参胶原蛋白来源的二肽基肽酶(dipeptidyl
peptidase-IV, DPP-IV) 抑制肽. 方法以仿刺参胶原蛋白序列为对象, 进行生物信息学分析和 …

Computational Modeling of the Interactions between DPP IV and Hemorphins

P Antony, B Baby, A Jobe, R Vijayan - International journal of molecular …, 2024 - mdpi.com
Type 2 diabetes is a chronic metabolic disorder characterized by high blood glucose levels
due to either insufficient insulin production or ineffective utilization of insulin by the body …