Thermoresponsive interfaces obtained using poly (N-isopropylacrylamide)-based copolymer for bioseparation and tissue engineering applications

K Nagase - Advances in Colloid and Interface Science, 2021 - Elsevier
Abstract Poly (N-isopropylacrylamide)(PNIPAAm) is the most well-known and widely used
stimuli-responsive polymer in the biomedical field owing to its ability to undergo temperature …

Thermoresponsive polymers with LCST transition: synthesis, characterization, and their impact on biomedical frontiers

Y Yuan, K Raheja, NB Milbrandt, S Beilharz… - RSC Applied …, 2023 - pubs.rsc.org
Advances in thermoresponsive materials have significantly impacted many biomedical
fields. The unique behavior of reversible phase transition close to the physiological …

[HTML][HTML] bFGF-releasing biodegradable nanoparticles for effectively engrafting transplanted hepatocyte sheet

K Nagase, M Nagaoka, Y Nakano, R Utoh - Journal of Controlled Release, 2024 - Elsevier
Hepatic tissue engineering has been applied for the treatment of intractable liver diseases,
and hepatocyte sheets are promising for this purpose. However, hepatocyte sheets have …

Umbilical cord-derived mesenchymal stem cell sheets transplanted subcutaneously enhance cell retention and survival more than dissociated stem cell injections

M Nakao, M Matsui, K Kim, N Nishiyama… - Stem Cell Research & …, 2023 - Springer
Background Human umbilical cord-derived mesenchymal stem cell (hUC-MSC) sheets have
recently attracted attention as an alternative approach to injected cell suspensions for stem …

Molecular bases for temperature sensitivity in supramolecular assemblies and their applications as thermoresponsive soft materials

H Liu, T Prachyathipsakul, TM Koyasseril-Yehiya… - Materials …, 2022 - pubs.rsc.org
Thermoresponsive supramolecular assemblies have been extensively explored in diverse
formats, from injectable hydrogels to nanoscale carriers, for a variety of applications …

Thermoresponsive mixed polymer brush to effectively control the adhesion and separation of stem cells by altering temperature

K Nagase, H Wakayama, J Matsuda, N Kojima… - Materials Today Bio, 2023 - Elsevier
During the last few decades, thermoresponsive materials for modulating cell adhesion have
been investigated for the application of tissue engineering. In this study, we developed …

Thermoresponsive block copolymer brush for temperature-modulated hepatocyte separation

K Nagase, N Kojima, M Goto, T Akaike… - Journal of Materials …, 2022 - pubs.rsc.org
Hepatic tissue engineering may be an effective approach for the treatment of liver disease;
however, its practical application requires hepatic cell separation technologies that do not …

Selective capture and non-invasive release of cells using a thermoresponsive polymer brush with affinity peptides

K Nagase, M Shimura, R Shimane, K Hanaya… - Biomaterials …, 2021 - pubs.rsc.org
Tissue engineering and cell transplantation therapy have become promising therapies for
intractable diseases. These approaches require cell separation technology without cell …

Thermally-modulated cell separation columns using a thermoresponsive block copolymer brush as a packing material for the purification of mesenchymal stem cells

K Nagase, G Edatsune, Y Nagata, J Matsuda… - Biomaterials …, 2021 - pubs.rsc.org
Cell therapy using mesenchymal stem cells (MSCs) is used as effective regenerative
treatment. Cell therapy requires effective cell separation without cell modification and …

[HTML][HTML] Thermoresponsive bio-affinity interfaces for temperature-modulated selective capture and release of targeted exosomes

K Nagase, K Yamazaki, Y Maekawa, H Kanazawa - Materials Today Bio, 2023 - Elsevier
The existing methods for exosome isolation, such as ultracentrifugation, size exclusion, and
affinity separation, suffer from some limitations. Herein, we aimed to develop temperature …