Red cell diseases encompass a group of inherited or acquired erythrocyte disorders that
affect the structure, function, or production of red blood cells (RBCs). These disorders can …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Haemoglobin (Hb) is widely known as the iron-containing protein in blood that is essential
for O 2 transport in mammals. Less widely recognised is that erythrocyte Hb belongs to a …

Nitrite is one of the players in the broad nitrogen biogeochemical cycle. This nitrogen oxo-
anion is involved in key pathways crucial to life on Earth and to the planetary “recycling” of …

Despite numerous defenses, the brain is vulnerable to oxidative stress resulting from
ischemia/reperfusion. Excitotoxic stimulation of superoxide and nitric oxide production leads …

The endothelium is not considered to be a major energy-requiring organ, but nevertheless
endothelial cells have an extensive mitochondrial network. This suggests that mitochondrial …

Organisms that tolerate wide variations in oxygen availability, especially to hypoxia, usually
face harsh environmental conditions during their lives. Such conditions include, for example …

Nitric oxide (NO) affects two key aspects of O2 supply and demand: It regulates vascular
tone and blood flow by activating soluble guanylate cyclase (sGC) in the vascular smooth …

▪ Abstract Blood flow in the microcirculation is regulated by physiological oxygen (O2)
gradients that are coupled to vasoconstriction or vasodilation, the domain of nitric oxide (NO) …

In human organism, the gaseous radical molecule nitric oxide (NO) is produced in various
cells from l-arginine by the catalytic action of NO synthases (NOS). The metabolic fate of NO …