[HTML][HTML] Links between COVID-19 and Parkinson's disease/Alzheimer's disease: reciprocal impacts, medical care strategies and underlying mechanisms
P Huang, LY Zhang, YY Tan, SD Chen - Translational Neurodegeneration, 2023 - Springer
The impact of coronavirus disease 2019 (COVID-19) pandemic on patients with
neurodegenerative diseases and the specific neurological manifestations of COVID-19 have …
neurodegenerative diseases and the specific neurological manifestations of COVID-19 have …
[HTML][HTML] Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA. 1 attenuation
Abstract The SARS-CoV-2 Omicron variant is more immune evasive and less virulent than
other major viral variants that have so far been recognized,,,,,,,,,,–. The Omicron spike (S) …
other major viral variants that have so far been recognized,,,,,,,,,,–. The Omicron spike (S) …
[HTML][HTML] In vitro and in vivo characterization of SARS-CoV-2 resistance to ensitrelvir
M Kiso, S Yamayoshi, S Iida, Y Furusawa… - Nature …, 2023 - nature.com
Ensitrelvir, an oral antiviral agent that targets a SARS-CoV-2 main protease (3CLpro or
Nsp5), is clinically useful against SARS-CoV-2 including its omicron variants. Since most …
Nsp5), is clinically useful against SARS-CoV-2 including its omicron variants. Since most …
Interaction of SARS-CoV-2 with host cells and antibodies: experiment and simulation
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the devastating global COVID-19 pandemic announced by WHO in March 2020. Through …
the devastating global COVID-19 pandemic announced by WHO in March 2020. Through …
[HTML][HTML] Omicron subvariant BA. 5 efficiently infects lung cells
Abstract The SARS-CoV-2 Omicron subvariants BA. 1 and BA. 2 exhibit reduced lung cell
infection relative to previously circulating SARS-CoV-2 variants, which may account for their …
infection relative to previously circulating SARS-CoV-2 variants, which may account for their …
[HTML][HTML] In SARS-CoV-2 delta variants, Spike-P681R and D950N promote membrane fusion, Spike-P681R enhances spike cleavage, but neither substitution affects …
Y Furusawa, M Kiso, S Iida, R Uraki, Y Hirata, M Imai… - …, 2023 - thelancet.com
Summary Background The SARS-CoV-2 delta (B. 1.617. 2 lineage) variant was first
identified at the end of 2020 and possessed two unique amino acid substitutions in its spike …
identified at the end of 2020 and possessed two unique amino acid substitutions in its spike …
[PDF][PDF] Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes several proteins
that inhibit host interferon responses. Among these, ORF6 antagonizes interferon signaling …
that inhibit host interferon responses. Among these, ORF6 antagonizes interferon signaling …
[HTML][HTML] The viral fitness and intrinsic pathogenicity of dominant SARS-CoV-2 Omicron sublineages BA. 1, BA. 2, and BA. 5
Summary Background Among the Omicron sublineages that have emerged, BA. 1, BA. 2,
BA. 5, and their related sublineages have resulted in the largest number of infections. While …
BA. 5, and their related sublineages have resulted in the largest number of infections. While …
Age-dependent acquisition of pathogenicity by SARS-CoV-2 Omicron BA. 5
B Imbiakha, S Ezzatpour, DW Buchholz, J Sahler… - Science …, 2023 - science.org
Pathology studies of SARS-CoV-2 Omicron variants of concern (VOC) are challenged by the
lack of pathogenic animal models. While Omicron BA. 1 and BA. 2 replicate in K18-hACE2 …
lack of pathogenic animal models. While Omicron BA. 1 and BA. 2 replicate in K18-hACE2 …
[HTML][HTML] Characterization of SARS-CoV-2 Omicron BA. 2.75 clinical isolates
R Uraki, S Iida, PJ Halfmann, S Yamayoshi… - Nature …, 2023 - nature.com
The prevalence of the Omicron subvariant BA. 2.75 rapidly increased in India and Nepal
during the summer of 2022, and spread globally. However, the virological features of BA …
during the summer of 2022, and spread globally. However, the virological features of BA …