SLC7A11/xCT is an antiporter that mediates the uptake of extracellular cystine in exchange
for glutamate. Cystine is reduced to cysteine, which is a rate-limiting precursor in glutathione …

The tripeptide glutathione (GSH), namely γ-L-glutamyl-L-cysteinyl-glycine, is an ubiquitous
low-molecular weight thiol nucleophile and reductant of utmost importance, representing the …

Objectives Evidences demonstrate that sorafenib alleviates liver fibrosis via inhibiting HSC
activation and ECM accumulation. The underlying mechanism remains unclear. Ferroptosis …

Regulation of RNA processing contributes profoundly to tissue development and physiology.
Here, we report that serine-arginine-rich splicing factor 1 (SRSF1) is essential for hepatocyte …

Identifying new pathways that regulate mammalian regeneration is challenging due to the
paucity of in vivo screening approaches. We employed pooled CRISPR knockout and …

Despite the crucial role of cell metabolism in biological processes, particularly cell division,
metabolic aspects of liver regeneration are not well defined. Better understanding of the …

The adult liver has an exceptional ability to regenerate, but how it maintains its specialized
functions during regeneration is unclear. Here, we used partial hepatectomy (PHx) in …

Abstract Background & Aims The outcome of liver injury is dictated by factors that control the
accumulation of myofibroblastic (activated) hepatic stellate cells (MF‐HSCs) but therapies …

Following injury, the liver's epithelial cells regenerate efficiently with rapid proliferation of
hepatocytes and biliary cells. However, when proliferation of resident epithelial cells is …

Neoplastic cells need to adapt their gene expression pattern to survive in an ever-changing
or unfavorable tumor microenvironment. Protein synthesis (or mRNA translation), an …