Risk factors and prevention of hepatocellular carcinoma in the era of precision medicine

N Fujiwara, SL Friedman, N Goossens, Y Hoshida - Journal of hepatology, 2018 - Elsevier
Patients who develop chronic fibrotic liver disease, caused by viral or metabolic aetiologies,
are at a high risk of developing hepatocellular carcinoma (HCC). Even after complete HCC …

Cyanobacterial blooms in China: diversity, distribution, and cyanotoxins

D Huo, N Gan, R Geng, Q Cao, L Song, G Yu, R Li - Harmful Algae, 2021 - Elsevier
Cyanobacterial blooms, which refer to the massive growth of harmful cyanobacteria, have
altered the global freshwater ecosystems during the past decades. China has the largest …

The burden and trends of primary liver cancer caused by specific etiologies from 1990 to 2017 at the global, regional, national, age, and sex level results from the …

L Lin, L Yan, Y Liu, C Qu, J Ni, H Li - Liver Cancer, 2020 - karger.com
Background: Liver cancer is one of the leading causes of cancer-related deaths worldwide.
The primary causes of liver cancer include hepatitis B virus (HBV), hepatitis C virus (HCV) …

The diversity of cyanobacterial toxins on structural characterization, distribution and identification: A systematic review

X Du, H Liu, L Yuan, Y Wang, Y Ma, R Wang, X Chen… - Toxins, 2019 - mdpi.com
The widespread distribution of cyanobacteria in the aquatic environment is increasing the
risk of water pollution caused by cyanotoxins, which poses a serious threat to human health …

Microcystin-LR combined with cadmium exposures and the risk of chronic kidney disease: a case–control study in Central China

S Feng, S Deng, Y Tang, Y Liu, Y Yang… - Environmental …, 2022 - ACS Publications
Increasing evidence indicates that exposure to microcystin-LR (MC-LR) can cause kidney
damage. However, the association between MC-LR exposure and chronic kidney disease …

A complete route for biodegradation of potentially carcinogenic cyanotoxin microcystin-LR in a novel indigenous bacterium

F Yang, F Huang, H Feng, J Wei, IY Massey, G Liang… - Water research, 2020 - Elsevier
Abstract Microcystin-leucine-arginine (MC-LR), a cyclic potentially carcinogenic hepatotoxin,
occurs frequently in aquatic habitats worldwide and seriously threatens ecosystem and …

Update on the adverse effects of microcystins on the liver

L Shi, X Du, H Liu, X Chen, Y Ma, R Wang, Z Tian… - Environmental …, 2021 - Elsevier
Microcystins (MCs) are the most common cyanobacteria toxins in eutrophic water, which
have strong hepatotoxicity. In the past decade, epidemiological and toxicological studies on …

Effects of cyanobacterial toxins on the human gastrointestinal tract and the mucosal innate immune system

B Kubickova, P Babica, K Hilscherová… - Environmental Sciences …, 2019 - Springer
Background Cyanobacterial blooms occur with increasing frequency in freshwater
ecosystems, posing a hazard to human and environmental health. Exposure of human to …

Cyanotoxins and food contamination in developing countries: Review of their types, toxicity, analysis, occurrence and mitigation strategies

MF Abdallah, WHR Van Hassel, M Andjelkovic… - Toxins, 2021 - mdpi.com
Cyanotoxins have gained global public interest due to their potential to bioaccumulate in
food, which threatens human health. Bloom formation is usually enhanced under …

Microcystin-LR ameliorates pulmonary fibrosis via modulating CD206+ M2-like macrophage polarization

J Wang, L Xu, Z Xiang, Y Ren, X Zheng, Q Zhao… - Cell death & …, 2020 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a group of chronic interstitial pulmonary diseases
characterized by myofibroblast proliferation and extracellular matrix deposition with limited …