The iron group transition-metal (Fe, Ru, Os) coordination of Se-doped graphitic carbon (Se@ gC 3 N 4) nanostructures for the smart therapeutic delivery of zidovudine …

FA Nelson, H Louis, I Benjamin, RA Timothy - RSC advances, 2023 - pubs.rsc.org
This study employed density functional theory (DFT) computational techniques at the
ωB97XD/def2svp level of theory to comprehensively explore the electronic behavior of Fe …

[HTML][HTML] Discovery of Benzisothiazolone Derivatives as Bifunctional Inhibitors of HIV-1 Reverse Transcriptase DNA Polymerase and Ribonuclease H Activities

A Vázquez Rivera, H Donald, M Alaoui-El-Azher… - Biomolecules, 2024 - mdpi.com
The ribonuclease H (RNase H) active site of HIV-1 reverse transcriptase (RT) is the only viral
enzyme not targeted by approved antiretroviral drugs. Using a fluorescence-based in vitro …

Lactic acid produced by optimal vaginal Lactobacillus species potently inactivates HIV-1 by several mechanisms including promoting inhibition of virion-associated …

M Aldunate, D Tyssen, A Johnson, CL Latham… - 2024 - researchsquare.com
Background. An optimal vaginal microbiota dominated by Lactobacillus spp. protects women
against acquiring and transmitting HIV in contrast to a nonoptimal vaginal microbiota …

[HTML][HTML] Bending the Curve Through Innovations to Overcome Persistent Obstacles in HIV Prevention and Treatment

TA Addissouky, IET El Sayed, MMA Ali… - Journal of AIDS and …, 2024 - scientificarchives.com
Background: HIV/AIDS remains a major global public health challenge despite significant
progress in treatment. New infections and HIV-related deaths persist, fueled by disparities in …

[HTML][HTML] Antiviral activity of myricetin glycosylated compounds isolated from Marcetia taxifolia against chikungunya virus

AL Muñoz, AF Cuéllar, G Arévalo, BD Santamaría… - EXCLI …, 2023 - ncbi.nlm.nih.gov
The chikungunya virus (CHIKV) has produced epidemic outbreaks of significant public
health impact. The clinical symptoms of this disease are fever, polyarthralgia, and skin rash …