Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human …

Molecular inputs to chromatin via cellular metabolism are modifiers of the epigenome. These
inputs—which include both nutrient availability as a result of diet and growth factor signalling …

Methionine uptake and metabolism is involved in a host of cellular functions including
methylation reactions, redox maintenance, polyamine synthesis and coupling to folate …

Methionine restriction (MetR) extends lifespan across different species and exerts beneficial
effects on metabolic health and inflammatory responses. In contrast, certain cancer cells …

The essential amino acid, methionine, is important for cancer cell growth and metabolism. A
growing body of evidence indicates that methionine restriction inhibits cancer cell growth …

Cellular metabolism has emerged as a major biological node governing cellular behaviour.
Metabolic pathways fuel cellular energy needs, providing basic chemical molecules to …

The process of DNA CpG methylation has been extensively investigated for over 50 years
and revealed associations between changing methylation status of CpG islands and gene …

Methionine is the initiator amino acid for protein synthesis, the methyl source for most
nucleotide, chromatin, and protein methylation, and the carbon backbone for various …

Objectives Dietary restriction of methionine (Met) and cysteine (Cys) delays the aging
process and aging-related diseases, improves glucose and fat metabolism and reduces …

Many chromatin-modifying enzymes require metabolic cofactors to support their catalytic
activities, providing a direct path for fluctuations in metabolite availability to regulate the …