Protein moonlighting: what is it, and why is it important?

CJ Jeffery - … transactions of the Royal Society B …, 2018 - royalsocietypublishing.org
Members of the GroEL/HSP60 protein family have been studied for many years because of
their critical roles as ATP-dependent molecular chaperones, so it might come as a surprise …

Aminoacyl-tRNA synthetases: on anti-synthetase syndrome and beyond

AS Galindo-Feria, A Notarnicola, IE Lundberg… - Frontiers in …, 2022 - frontiersin.org
Anti-synthetase syndrome (ASSD) is an autoimmune disease characterized by the presence
of autoantibodies targeting one of several aminoacyl t-RNA synthetases (aaRSs) along with …

New functions of aminoacyl-tRNA synthetases beyond translation

M Guo, XL Yang, P Schimmel - Nature reviews Molecular cell biology, 2010 - nature.com
Over the course of evolution, eukaryotic aminoacyl-tRNA synthetases (aaRSs) progressively
incorporated domains and motifs that have no essential connection to aminoacylation …

Aminoacyl‐tRNA synthetases in medicine and disease

P Yao, PL Fox - EMBO molecular medicine, 2013 - embopress.org
Aminoacyl‐tRNA synthetases (ARSs) are essential and ubiquitous 'house‐keeping'enzymes
responsible for charging amino acids to their cognate tRNAs and providing the substrates for …

Aminoacyl tRNA synthetases and their connections to disease

SG Park, P Schimmel, S Kim - Proceedings of the National …, 2008 - National Acad Sciences
Aminoacylation of transfer RNAs establishes the rules of the genetic code. The reactions are
catalyzed by an ancient group of 20 enzymes (one for each amino acid) known as …

Aminoacyl-tRNA synthetases and tumorigenesis: more than housekeeping

S Kim, S You, D Hwang - Nature Reviews Cancer, 2011 - nature.com
Over the past decade, the identification of cancer-associated factors has been a subject of
primary interest not only for understanding the basic mechanisms of tumorigenesis but also …

The GAIT system: a gatekeeper of inflammatory gene expression

R Mukhopadhyay, J Jia, A Arif, PS Ray… - Trends in biochemical …, 2009 - cell.com
Functionally related genes are coregulated by specific RNA–protein interactions that direct
transcript-selective translational control. In myeloid cells, interferon (IFN)-γ induces formation …

The distal hereditary motor neuropathies

AM Rossor, B Kalmar, L Greensmith… - Journal of Neurology …, 2012 - jnnp.bmj.com
The distal hereditary motor neuropathies (dHMN) comprise a heterogenous group of
diseases that share the common feature of a length-dependent predominantly motor …

Selective and specific inhibition of the Plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin

D Hoepfner, CW McNamara, CS Lim, C Studer… - Cell host & …, 2012 - cell.com
With renewed calls for malaria eradication, next-generation antimalarials need be active
against drug-resistant parasites and efficacious against both liver-and blood-stage …

tRNA synthetase: tRNA aminoacylation and beyond

YLJ Pang, K Poruri, SA Martinis - Wiley Interdisciplinary …, 2014 - Wiley Online Library
The aminoacyl‐tRNA synthetases are prominently known for their classic function in the first
step of protein synthesis, where they bear the responsibility of setting the genetic code. Each …