Long known as terminal degradation stations, lysosomes have emerged as sophisticated
signalling centres that govern cell growth, division and differentiation. Lysosomes interface …

Lysosomal storage diseases (LSDs) are a group of over 70 diseases that are characterized
by lysosomal dysfunction, most of which are inherited as autosomal recessive traits. These …

Activation of cellular stress response pathways to maintain metabolic homeostasis is
emerging as a critical growth and survival mechanism in many cancers. The pathogenesis of …

The lysosome has long been viewed as the recycling center of the cell. However, recent
discoveries have challenged this simple view and have established a central role of the …

The mechanistic target of rapamycin complex I (mTORC1) is a central regulator of cellular
and organismal growth, and hyperactivation of this pathway is implicated in the …

Lysosomes coordinate cellular metabolism and growth upon sensing of essential nutrients,
including cholesterol. Through bioinformatic analysis of lysosomal proteomes, we identified …

Endocytosis is a fundamental process in which eukaryotic cells internalise molecules and
macromolecules via deformation of the membrane and generation of membrane-bound …

In metazoans, lysosomes are the center for the degradation of macromolecules and play a
key role in a variety of cellular processes, such as autophagy, exocytosis and membrane …

Lysosomes are the primary catabolic compartments of eukaryotic cells. They degrade
extracellular material that has been internalized by endocytosis and intracellular …

Hexanucleotide expansion in an intron of the C9orf72 gene causes amyotrophic lateral
sclerosis and frontotemporal dementia. However, beyond bioinformatics predictions that …