Individual transcription factors in the brain frequently display broad functional versatility,
thereby controlling multiple cellular outputs. In accordance, neuron-restricted mutagenesis …

Accumulating evidence suggests that the serum response factor (SRF) cofactor
megakaryoblastic leukemia (MKL)/myocardin-related transcription factor (MRTF) has critical …

Numerous motile cell functions depend on signaling from the cytoskeleton to the nucleus.
Myocardin-related transcription factors (MRTFs) translocate to the nucleus in response to …

Serum response factor (SRF) is a prototypic transcription factor that mediates stimulus-
dependent gene expression. Here, we show that SRF mediates NGF signaling, axonal …

Abstract Myocardia-Related Transcription Factors-A (MRTF-A), which is enriched in the
hippocampus and cerebral cortex, has been shown to have a protective function against …

The growth of axons is an intricately regulated process involving intracellular signaling
cascades and gene transcription. We had previously shown that the stimulus-dependent …

Serum response factor (SRF) is a major transcription factor that regulates activity-driven
gene expression in neurons. Activation of SRF-driven transcription occurs through its …

Background Rett syndrome (RTT) is a neurodevelopmental disorder mainly caused by
mutations in the methyl-CpG-binding protein 2 gene (MECP2). MeCP2 is a multi-functional …

Serum response factor (SRF) is a representative transcription factor that plays crucial roles
in various biological phenomena by regulating immediate early genes (IEGs) and genes …

Dynamic changes in neuronal morphology and transcriptional regulation play crucial roles
in the neuronal network and function. Accumulating evidence suggests that the …