Abstract Treatment of primary intraocular uveal melanoma has developed considerably, its
driver genes are largely unraveled, and the ways to assess its risk for metastases are very …

Uveal melanoma (UM), a rare cancer of the eye, is distinct from cutaneous melanoma by its
etiology, the mutation frequency and profile, and its clinical behavior including resistance to …

Circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) have been recently
investigated in several cancer types, but their respective clinical significance remains to be …

Uveal melanoma (UM) is the most common primary intraocular malignancy affecting adults.
Despite successful local treatment of the primary tumour, metastatic disease develops in up …

Uveal melanoma (UM) is a type of intraocular tumor with a propensity to disseminate to the
liver. Despite the identification of the early driver mutations during the development of the …

Tumor biopsy can identify prognostic biomarkers for metastatic uveal melanoma (UM),
however aqueous humor (AH) liquid biopsy may serve as an adjunct. This study …

Simple Summary Uveal melanoma is an aggressive cancer that begins in the eye, but often
spreads to distant organs when tumor cells enter the blood. Disease spreads in nearly half …

Background: The availability of molecular-targeted therapies for the treatment of melanoma
has emphasised the need to identify mutations in target genes such as BRAF and KIT …

The detection of metastases in patients with a diagnosis of uveal melanoma (UM) is a
controversial issue. While only 1% of the patients have detectable metastases at the time of …

In the era of precision oncology, major strides are being made to use individual tumor
information for clinical decision-making. Differing from traditional biopsy methods, the …