Differentiating protein-coding and noncoding RNA: challenges and ambiguities
The assumption that RNA can be readily classified into either protein-coding or non-protein–
coding categories has pervaded biology for close to 50 years. Until recently, discrimination …
coding categories has pervaded biology for close to 50 years. Until recently, discrimination …
Rapid evolution of noncoding RNAs: lack of conservation does not mean lack of function
The mammalian transcriptome contains many non-protein-coding RNAs (ncRNAs), but most
of these are of unclear significance and lack strong sequence conservation, prompting …
of these are of unclear significance and lack strong sequence conservation, prompting …
Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAs
Most metazoan microRNAs (miRNAs) target many genes for repression, but the nematode
lsy-6 miRNA is much less proficient. Here we show that the low proficiency of lsy-6 can be …
lsy-6 miRNA is much less proficient. Here we show that the low proficiency of lsy-6 can be …
The impact of microRNAs on protein output
MicroRNAs are endogenous∼ 23-nucleotide RNAs that can pair to sites in the messenger
RNAs of protein-coding genes to downregulate the expression from these messages …
RNAs of protein-coding genes to downregulate the expression from these messages …
The ENCODE (ENCyclopedia of DNA elements) project
EA Feingold, PJ Good, MS Guyer, S Kamholz… - Science, 2004 - scholarworks.bwise.kr
The ENCyclopedia Of DNA Elements (ENCODE) Project aims to identify all functional
elements in the human genome sequence. The pilot phase of the Project is focused on a …
elements in the human genome sequence. The pilot phase of the Project is focused on a …
Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution
Project management: Fulton Lucinda A. 1 Mardis … - Nature, 2004 - nature.com
We present here a draft genome sequence of the red jungle fowl, Gallus gallus. Because the
chicken is a modern descendant of the dinosaurs and the first non-mammalian amniote to …
chicken is a modern descendant of the dinosaurs and the first non-mammalian amniote to …
Human long non‐coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors
Long non‐coding RNAs (lncRNAs) are a numerous class of newly discovered genes in the
human genome, which have been proposed to be key regulators of biological processes …
human genome, which have been proposed to be key regulators of biological processes …
Global reconstruction of the human metabolic network based on genomic and bibliomic data
NC Duarte, SA Becker, N Jamshidi… - Proceedings of the …, 2007 - National Acad Sciences
Metabolism is a vital cellular process, and its malfunction is a major contributor to human
disease. Metabolic networks are complex and highly interconnected, and thus systems-level …
disease. Metabolic networks are complex and highly interconnected, and thus systems-level …
Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution
J Cheng, P Kapranov, J Drenkow, S Dike, S Brubaker… - science, 2005 - science.org
Sites of transcription of polyadenylated and nonpolyadenylated RNAs for 10 human
chromosomes were mapped at 5–base pair resolution in eight cell lines. Unannotated …
chromosomes were mapped at 5–base pair resolution in eight cell lines. Unannotated …
Genome-wide transcription and the implications for genomic organization
Recent evidence of genome-wide transcription in several species indicates that the amount
of transcription that occurs cannot be entirely accounted for by current sets of genome-wide …
of transcription that occurs cannot be entirely accounted for by current sets of genome-wide …