Ovarian cancer is the leading cause of gynecological cancer-related death. Drug resistance
is the bottleneck in ovarian cancer treatment. The increasing use of novel drugs in clinical …

ABC transporters play a critical role in both drug bioavailability and toxicity, and with the
discovery of the P-glycoprotein (P-gp), this became even more evident, as it plays an …

P-Glycoprotein (P-gp) is a transmembrane protein belonging to the ATP binding cassette
superfamily of transporters, and it is a xenobiotic efflux pump that limits intracellular drug …

The ATP-dependent membrane transporter P-glycoprotein (P-gp) is associated with
resistance to a wide variety of chemical substrates, as well as the multi-drug resistance …

The membrane efflux transporter P-glycoprotein (P-gp,[ABCB1, MDR1]) exports a wide
range of xenobiotic compounds, resulting in a continuous first line of defense against …

Drug metabolism and transport, orchestrated by drug-metabolizing enzymes (DMEs) and
drug transporters (DTs), are implicated in drug–drug interactions (DDIs) and adverse drug …

In this study, some new quinoline-carboxamide derivatives possessing a flexible
(dimethylamino) ethylcarboxamide side chain were synthesized as DNA intercalating …

P-glycoprotein (Pgp) is a member of the ATP-binding cassette family of transporters that
confers multidrug resistance to cancer cells and is actively involved in the pharmacokinetics …

Ethnopharmacological relevance The existence of the blood-brain barrier/blood tumor
barrier (BBB/BTB) severely restricts the effectiveness of anti-tumor drugs, thus glioma is still …

Dendrobium candidum (DC) is an agricultural product for both food and medicine. It has a
variety of beneficial effects on the human body with antioxidant, anti-inflammatory, antitumor …