Bacillus thuringiensis insecticidal three-domain Cry toxins: mode of action, insect resistance and consequences for crop protection

L Pardo-López, M Soberón… - FEMS microbiology …, 2013 - academic.oup.com
Bacillus thuringiensis bacteria are insect pathogens that produce different Cry and Cyt toxins
to kill their hosts. Here we review the group of three-domain Cry (3d-Cry) toxins. Expression …

Bacillus thuringiensis: a story of a successful bioinsecticide

A Bravo, S Likitvivatanavong, SS Gill… - Insect biochemistry and …, 2011 - Elsevier
Bacillus thuringiensis (Bt) bacteria are insect pathogens that rely on insecticidal pore
forming proteins known as Cry and Cyt toxins to kill their insect larval hosts. At least four …

Diversity of Bacillus thuringiensis crystal toxins and mechanism of action

MJ Adang, N Crickmore, JL Jurat-Fuentes - Advances in insect physiology, 2014 - Elsevier
Parasporal crystals produced by Bacillus thuringiensis (Bt) bacteria are the main virulence
factors underlying Bt toxicity to insects. Parasporal crystals are composed primarily of Cry …

[HTML][HTML] Pore formation: an ancient yet complex form of attack

I Iacovache, FG van der Goot, L Pernot - Biochimica et Biophysica Acta …, 2008 - Elsevier
Bacteria, as well as higher organisms such as sea anemones or earthworms, have
developed sophisticated virulence factors such as the pore-forming toxins (PFTs) to mount …

Pore formation by Cry toxins

M Soberón, L Pardo, C Muñóz-Garay… - … membrane binding and …, 2010 - Springer
B acillus thuringiensis (Bt) bacteria produce insecticidal Cry and Cyt proteins used in the
biological control of different insect pests. In this review, we will focus on the 3d-Cry toxins …

The membrane attack complex, perforin and cholesterol-dependent cytolysin superfamily of pore-forming proteins

N Lukoyanova, BW Hoogenboom… - Journal of Cell …, 2016 - journals.biologists.com
The membrane attack complex and perforin proteins (MACPFs) and bacterial cholesterol-
dependent cytolysins (CDCs) are two branches of a large and diverse superfamily of pore …

Mosquito resistance to bacterial larvicidal toxins

MC Wirth - The Open Toxinology Journal, 2010 - benthamopen.com
Insecticide resistance to the microbial insecticides Bacillus thuringiensis subsp. israelensis
(Bti) and Bacillus sphaericus (Bs) represents a serious threat to their success. Available …

Channel Formation in Cry Toxins: An Alphafold-2 Perspective

J Torres, W Surya, P Boonserm - International journal of molecular …, 2023 - mdpi.com
Bacillus thuringiensis (Bt) strains produce pore-forming toxins (PFTs) that attack insect pests.
Information for pre-pore and pore structures of some of these Bt toxins is available. However …

Single molecule fluorescence study of the Bacillus thuringiensis toxin Cry1Aa reveals tetramerization

N Groulx, H McGuire, R Laprade, JL Schwartz… - Journal of Biological …, 2011 - ASBMB
Pore-forming toxins constitute a class of potent virulence factors that attack their host
membrane in a two-or three-step mechanism. After binding to the membrane, often aided by …

Potential prepore trimer formation by the Bacillus thuringiensis mosquito-specific toxin: Molecular insights into a critical prerequisite of membrane-bound monomers

W Sriwimol, A Aroonkesorn, S Sakdee… - Journal of Biological …, 2015 - ASBMB
The insecticidal feature of the three-domain Cry δ-endotoxins from Bacillus thuringiensis is
generally attributed to their capability to form oligomeric pores, causing lysis of target larval …