New developments in RiPP discovery, enzymology and engineering

M Montalbán-López, TA Scott, S Ramesh… - Natural product …, 2021 - pubs.rsc.org
Covering: up to June 2020 Ribosomally-synthesized and post-translationally modified
peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 …

RiPP antibiotics: biosynthesis and engineering potential

GA Hudson, DA Mitchell - Current opinion in microbiology, 2018 - Elsevier
The threat of antibiotic resistant bacterial infections continues to underscore the need for
new treatment options. Historically, small molecule metabolites from microbes have …

Selective Oxidation of 5-Hydroxymethylfurfural to 2,5-Furandicarboxylic Acid Using O2 and a Photocatalyst of Co-thioporphyrazine Bonded to gC3N4

S Xu, P Zhou, Z Zhang, C Yang, B Zhang… - Journal of the …, 2017 - ACS Publications
Selective oxidation of 5-hydroxymethylfurfural (HMF) to 2, 5-furandicarboxylic acid (FDCA) is
one of the key reactions for producing chemical commodities from biomass and their …

Bioinformatic Mapping of Radical S-Adenosylmethionine-Dependent Ribosomally Synthesized and Post-Translationally Modified Peptides Identifies New Cα, Cβ …

GA Hudson, BJ Burkhart, AJ DiCaprio… - Journal of the …, 2019 - ACS Publications
Recently developed bioinformatic tools have bolstered the discovery of ribosomally
synthesized and post-translationally modified peptides (RiPPs). Using an improved version …

Introduction to thiopeptides: biological activity, biosynthesis, and strategies for functional reprogramming

AA Vinogradov, H Suga - Cell Chemical Biology, 2020 - cell.com
Thiopeptides (also known as thiazolyl peptides) are structurally complex natural products
with rich biological activities. Known for over 70 years for potent killing of Gram-positive …

Radical SAM enzymes in the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs)

A Benjdia, C Balty, O Berteau - Frontiers in chemistry, 2017 - frontiersin.org
Ribosomally-synthesized and post-translationally modified peptides (RiPPs) are a large and
diverse family of natural products. They possess interesting biological properties such as …

Macrocyclization via an Arginine-Tyrosine Crosslink Broadens the Reaction Scope of Radical S-Adenosylmethionine Enzymes

A Caruso, RJ Martinie, LB Bushin… - Journal of the …, 2019 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are an
ascendant class of natural products with diverse structures and functions. Recently, we …

Emulating nonribosomal peptides with ribosomal biosynthetic strategies

S Mordhorst, F Ruijne, AL Vagstad, OP Kuipers… - RSC Chemical …, 2023 - pubs.rsc.org
Peptide natural products are important lead structures for human drugs and many
nonribosomal peptides possess antibiotic activity. This makes them interesting targets for …

Radical S-Adenosylmethionine Enzymes Involved in RiPP Biosynthesis

N Mahanta, GA Hudson, DA Mitchell - Biochemistry, 2017 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) display a
diverse range of structures and continue to expand as a natural product class. Accordingly …

Ribosomal natural products, tailored to fit

MA Funk, WA Van Der Donk - Accounts of chemical research, 2017 - ACS Publications
Conspectus Ri bosomally synthesized and P ost-translationally modified P eptides (RiPPs)
take advantage of the ribosomal translation machinery to generate linear peptides that are …