Directed evolution aims to expedite the natural evolution process of biological molecules
and systems in a test tube through iterative rounds of gene diversifications and library …

Metalloenzymes catalyze a variety of reactions using a limited number of natural amino
acids and metallocofactors. Therefore, the environment beyond the primary coordination …

Conspectus Despite the astonishing diversity of naturally occurring biocatalytic processes,
enzymes do not catalyze many of the transformations favored by synthetic chemists. Either …

Based on the principles and metrics of green chemistry and sustainable development,
biocatalysis is both a green and sustainable technology. This is largely a result of the …

Tailor‐made: Discussed herein is the ability to adapt biology's mechanisms for innovation
and optimization to solving problems in chemistry and engineering. The evolution of nature's …

I am a chemist and engineer who looks upon the living world with the deepest admiration.
Nature, herself a brilliant chemist and by far the best engineer of all time, invented life that …

This Review is aimed at synthetic organic chemists who may be familiar with organometallic
catalysis but have no experience with biocatalysis, and seeks to provide an answer to the …

The ability of one enzyme to catalyse multiple, mechanistically distinct transformations likely
played a crucial role in organisms' abilities to adapt to changing external stimuli in the past …

Highlights•Engineered hemoproteins expand the biocatalytic repertoire.•Different
hemoprotein scaffolds offer diverse activities and selectivities.•New enzymes enable …

Recent advances in enzyme engineering and design have expanded nature's catalytic
repertoire to functions that are new to biology,,. However, only a subset of these engineered …