We have analyzed host cell genes linked to HIV replication that were identified in nine
genome-wide studies, including three independent siRNA screens. Overlaps among the …

HIV is a disease in which the original clinical observations of severe opportunistic infections
gave the first clues regarding the underlying pathology, namely that HIV is essentially an …

Fine-mapping to plausible causal variation may be more effective in multi-ancestry cohorts,
particularly in the MHC, which has population-specific structure. To enable such studies, we …

Identification of the transmitted/founder virus makes possible, for the first time, a genome-
wide analysis of host immune responses against the infecting HIV-1 proteome. A complete …

The rapid and extensive spread of the human immunodeficiency virus (HIV) epidemic
provides a rare opportunity to witness host–pathogen co-evolution involving humans. A focal …

Introduction Heterosexual HIV-1 transmission is an inefficient process with rates reported at<
1% per unprotected sexual exposure. When transmission occurs, systemic infection is …

Human immunodeficiency virus type 1 (HIV-1) elite controllers (EC) maintain viremia below
the limit of commercial assay detection (< 50 RNA copies/ml) in the absence of antiviral …

The course of immune maturation has evolved to favour survival at each stage of
development in early life. Fetal and neonatal immune adaptations facilitate intrauterine …

Background Despite the extensive genetic diversity of HIV-1, viral evolution in response to
immune selective pressures follows broadly predictable mutational patterns. Sites and …

Previous studies have identified a central role for HLA-B alleles in influencing control of HIV
infection. An alternative possibility is that a small number of HLA-B alleles may have a very …