Sepsis represents the host's systemic inflammatory response to a severe infection. It causes
substantial human morbidity resulting in hundreds of thousands of deaths each year …

Sepsis is a serious clinical condition that represents a patient's response to a severe
infection and has a very high mortality rate. Normal immune and physiologic responses …

Advanced glycation end products (AGEs), S100/calgranulins, HMGB1-proteins, amyloid-β
peptides, and the family of β-sheet fibrils have been shown to contribute to a number of …

While the initiation of the adaptive and innate immune response is well understood, less is
known about cellular mechanisms propagating inflammation. The receptor for advanced …

Polymicrobial diseases involve two or more microorganisms that act synergistically, or in
succession, to mediate complex disease processes. Although polymicrobial diseases in …

Objective: Lethal sepsis occurs when an excessive inflammatory response evolves that
cannot be controlled by physiologic anti-inflammatory mechanisms, such as the recently …

Background Inflammation in the early stages of sepsis is governed by the innate immune
response. Costimulatory molecules are a receptor/ligand class of molecules capable of …

Macrophages reside in all tissues as resident populations and as immigrants recruited in
response to tissue injury, inflammation or pathogen invasion. Under normal conditions …

Sepsis is a serious global health problem. In addition to a high incidence, this syndrome has
a high mortality and is responsible for huge health expenditure. The pathophysiology of …

Chlamydia trachomatis is a very common sexually transmissible infection in both developing
and developed countries. A hallmark of C. trachomatis infection is the induction of severe …