[HTML][HTML] Thymoquinone: A novel strategy to combat cancer: A review

M Imran, A Rauf, IA Khan, M Shahbaz… - Biomedicine & …, 2018 - Elsevier
The higher consumption of fruit, herbs, spices, and vegetables is well known and practical
strategy to cure human cancers owing to their presence of bioactive compounds. Among …

[HTML][HTML] Thymoquinone, as an anticancer molecule: from basic research to clinical investigation

MA Khan, M Tania, S Fu, J Fu - Oncotarget, 2017 - ncbi.nlm.nih.gov
Thymoquinone is an anticancer phytochemical commonly found in black cumin. In this
review, we discuss the potential of thymoquinone as anticancer molecule, its mechanism of …

Thymoquinone inhibits bone metastasis of breast cancer cells through abrogation of the CXCR4 signaling axis

MK Shanmugam, KS Ahn, A Hsu, CC Woo… - Frontiers in …, 2018 - frontiersin.org
Overexpression of chemokine receptor type 4 (CXCR4) has been found to be associated
with increased cell proliferation, metastasis and also act as an indicator of poor prognosis in …

Anticancer activity of thymoquinone cubic phase nanoparticles against human breast cancer: Formulation, cytotoxicity and subcellular localization

MM Mehanna, R Sarieddine, JK Alwattar… - International Journal …, 2020 - Taylor & Francis
Introduction Triple negative breast cancer is an aggressive disorder which accounts for at
least 15% of breast cancer diagnosis and a high percentage of breast cancer morbidity …

Antioxidant, Anti-Proliferative Activity and Chemical Fingerprinting of Centaurea calcitrapa against Breast Cancer Cells and Molecular Docking of Caspase-3

MAM Aboul-Soud, H Ennaji, A Kumar, MA Alfhili, A Bari… - Antioxidants, 2022 - mdpi.com
Centaurea calcitrapa has been intensively utilized in ethnomedicinal practices as a natural
therapeutic recipe to cure various ailments. The current study aimed to chemically …

Ibudilast attenuates folic acid–induced acute kidney injury by blocking pyroptosis through TLR4-mediated NF-κB and MAPK signaling pathways

X Li, Y Zou, YY Fu, J Xing, KY Wang, PZ Wan… - Frontiers in …, 2021 - frontiersin.org
Folic acid (FA)-induced renal tubule damage, which is characterized by extensive
inflammation, is a common model of acute kidney injury (AKI). Pyroptosis, a pro …

[HTML][HTML] The Influence of pluronic F68 and F127 nanocarrier on physicochemical properties, in vitro release, and antiproliferative activity of thymoquinone drug

S Shaarani, SS Hamid, NHM Kaus - Pharmacognosy research, 2017 - ncbi.nlm.nih.gov
Background: This study reports on hydrophobic drug thymoquinone (TQ), an active
compound found in the volatile oil of Nigella sativa that exhibits anticancer activities …

Modulation of diverse oncogenic transcription factors by thymoquinone, an essential oil compound isolated from the seeds of Nigella sativa Linn

MK Shanmugam, F Arfuso, AP Kumar, L Wang… - Pharmacological …, 2018 - Elsevier
Thymoquinone (TQ), isolated almost fifty years ago, is the main bioactive constituent of black
seed essential oil extracted from the seed of Nigella sativa. TQ has been shown to have …

Challenges and recent advances in medulloblastoma therapy

V Kumar, V Kumar, T McGuire, DW Coulter… - Trends in …, 2017 - cell.com
Medulloblastoma (MB) is the most common childhood brain tumor, which occurs in the
posterior fossa. MB tumors are highly heterogeneous and have diverse genetic make-ups …

Thymoquinone induces apoptosis of human renal carcinoma Caki-1 cells by inhibiting JAK2/STAT3 through pro-oxidant effect

IG Chae, NY Song, DH Kim, MY Lee, JM Park… - Food and Chemical …, 2020 - Elsevier
Currently, there are limited effective treatment options for renal cell carcinoma (RCC), due to
its poor responses to conventional therapies. Instead of using extrinsic anti-cancer drugs …