Naive T cells are actively maintained in a quiescent state that promotes their survival and
persistence. On antigen stimulation, T cells exit quiescence to initiate clonal expansion and …

The proper restraint of the destructive potential of the immune system is essential for
maintaining health. Regulatory T (Treg) cells ensure immune homeostasis through their …

CD4+ effector T cells (Teff cells) and regulatory T cells (Treg cells) undergo metabolic
reprogramming to support proliferation and immunological function. Although signaling via …

CD4+ T cells differentiate and acquire distinct functions to combat specific pathogens but
can also adapt their functions in response to changing circumstances. Although this …

It has been appreciated for nearly 100 years that cancer cells are metabolically distinct from
resting tissues. More recently understood is that this metabolic phenotype is not unique to …

Despite the clinical success of immune checkpoint blockade (ICB), in certain cancer types,
most patients with cancer do not respond well. Furthermore, in patients for whom ICB is …

Regulatory T (Treg) cells are crucial for peripheral immune tolerance and prevention of
autoimmunity and tissue damage. Treg cells are inherently defined by the expression of the …

Regulatory T (Treg) cells respond to immune and inflammatory signals to mediate
immunosuppression, but how the functional integrity of Treg cells is maintained under …

The evolutionarily conserved serine/threonine kinase mTOR (mechanistic target of
rapamycin) forms the distinct protein complexes mTORC1 and mTORC2 and integrates …

Regulatory T cells (Tregs) maintain immune homeostasis and prevent autoimmunity. Serine
stimulates glutathione (GSH) synthesis and feeds into the one-carbon metabolic network …