Veliparib (ABT-888), a PARP inhibitor potentiates the cytotoxic activity of 5-fluorouracil by inhibiting MMR pathway through deregulation of MSH6 in colorectal cancer …
Objective Sensitization of mismatch repair (MMR)-deficient colorectal cancer (CRC) cells by
5-Fluorouracil (5-FU) is well-documented. But not much is known about the treatment of …
5-Fluorouracil (5-FU) is well-documented. But not much is known about the treatment of …
Hyaluronic acid-empowered nanotheranostics in breast and lung cancers therapy
F Alsaikhan - Environmental Research, 2023 - Elsevier
Nanomedicine application in cancer therapy is an urgency because of inability of current
biological therapies for complete removal of tumor cells. The development of smart and …
biological therapies for complete removal of tumor cells. The development of smart and …
Talazoparib enhances the quinacrine-mediated apoptosis in patient-derived oral mucosa CSCs by inhibiting BER pathway through the modulation of GCN5 and P300
The presence of cancer stem cells (CSCs) in the tumor microenvironment (TME) is majorly
responsible for the development and recurrence of cancer. Earlier reports suggested that …
responsible for the development and recurrence of cancer. Earlier reports suggested that …
Nano formulated Resveratrol inhibits PD-L1 in oral cancer cells by deregulating the association between tumor associated macrophages and cancer associated …
Tumor associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs) in the
tumor microenvironment secrete several cytokines, which involved in tumor initiation …
tumor microenvironment secrete several cytokines, which involved in tumor initiation …
[HTML][HTML] Nanostructures for site-specific delivery of oxaliplatin cancer therapy: Versatile nanoplatforms in synergistic cancer therapy
M Bagheri, MA Zandieh, M Daryab, SS Samaei… - Translational …, 2024 - Elsevier
As a clinically approved treatment strategy, chemotherapy-mediated tumor suppression has
been compromised, and in spite of introducing various kinds of anticancer drugs, cancer …
been compromised, and in spite of introducing various kinds of anticancer drugs, cancer …
BRCA mutations—the Achilles heel of breast, ovarian and other epithelial cancers
AP Loboda, LS Adonin, SD Zvereva… - International journal of …, 2023 - mdpi.com
Two related tumor suppressor genes, BRCA1 and BRCA2, attract a lot of attention from both
fundamental and clinical points of view. Oncogenic hereditary mutations in these genes are …
fundamental and clinical points of view. Oncogenic hereditary mutations in these genes are …
The interlacing anticancer effect of pharmacologic ascorbate, chloroquine, and resveratrol
K Makk‐Merczel, D Varga, P Hajdinák, A Szarka - BioFactors, 2024 - Wiley Online Library
Currently, a diagnosis with KRAS mutant pancreatic ductal adenocarcinoma (PDAC) means
a death warrant, so finding efficient therapeutic options is a pressing issue. Here, we …
a death warrant, so finding efficient therapeutic options is a pressing issue. Here, we …
Combination of Resveratrol and PARP inhibitor Olaparib efficiently deregulates homologous recombination repair pathway in breast cancer cells through inhibition of …
Recently, we reported that a combination of a natural, bioactive compound Resveratrol
(RES) and a PARP inhibitor Olaparib (OLA) deregulated the homologous recombination …
(RES) and a PARP inhibitor Olaparib (OLA) deregulated the homologous recombination …
Near infrared-responsive quinacrine–gold hybrid nanoparticles deregulate HSP-70/P300-mediated H3K14 acetylation in ER/PR+ breast cancer stem cells
Aim: This study aimed to determine if quinacrine–gold hybrid nanoparticles (QAuNPs)+ near-
infrared (NIR) deregulate HSP-70/P300 complex-mediated H3K14 acetylation in estrogen …
infrared (NIR) deregulate HSP-70/P300 complex-mediated H3K14 acetylation in estrogen …
Quinacrine inhibits cMET-mediated metastasis and angiogenesis in breast cancer stem cells
A trans-membrane receptor tyrosine kinase, cMET, belonging to the MET proto-oncogene
family, is responsible for cancer metastasis and angiogenesis. But not much is known about …
family, is responsible for cancer metastasis and angiogenesis. But not much is known about …