Background It has been reported that neural tube defects (NTD) can be prevented with
periconceptional folic acid supplementation. The effects of different doses, forms and …

Vitamin B12 (hereafter referred to as B12) deficiency in pregnancy is prevalent and has
been associated with both lower birth weight (birth weight< 2,500 g) and preterm birth …

The importance of folate in reproduction can be appreciated by considering that the
existence of the vitamin was first suspected from efforts to explain a potentially fatal …

ABSTRACT Vitamin B-12 deficiency (< 148 pmol/L) is associated with adverse maternal and
neonatal outcomes, including developmental anomalies, spontaneous abortions …

Despite worldwide public-health campaigns recommending periconceptional daily
supplementation of synthetic folic acid to reduce the risk of neural tube defects, many …

Background: Vitamin B-12 and folate are micronutrients essential for normal embryogenesis.
Vitamin B-12 insufficiency in pregnancy is high in certain parts of the world, such as India …

One carbon metabolism (OCM) is critical for early development, as it provides one carbon
(1C) units for the biosynthesis of DNA, proteins, and lipids and epigenetic modification of the …

The beneficial effect of folic acid supplementation before and shortly after conception is well
recognized, whereas the effect of supplementation during the second and third trimesters is …

Abstract Aims/hypothesis In an Indian birth cohort, higher maternal homocysteine
concentration in pregnancy was associated with lower birthweight of the offspring. Lower …

Smoking is associated with oxidative stress and increased risks of many chronic diseases
that both shorten life and impair its quality. Low concentrations of several micronutrients …