There is growing evidence that patients with Type 2 diabetes have an increased risk of
developing Parkinson's disease and share similar dysregulated pathways suggesting …

Leptin is the most critical hormone in the homeostatic regulation of energy balance among
those so far discovered. Leptin primarily acts on the neurons of the mediobasal part of …

Insulin resistance, the most important characteristic of the type 2 diabetes mellitus (T2DM), is
mostly caused by impairment in the insulin receptor (IR) signal transduction pathway …

Inflammation is the common pathological basis of autoimmune diseases, metabolic
diseases, malignant tumors, and other major chronic diseases. Inflammation plays an …

The aim of this review was to discuss an overview of type 2 diabetes; biology of PTP1B; role
of PTP1B in metabolic disorders; and recent updates in the development of PTP1B inhibitors …

Protein tyrosine phosphatase 1B (PTP1B) is a typical member of the PTP family, considered
a direct negative regulator of several receptor and receptor-associated tyrosine kinases …

The aggregation of α-synuclein, an intrinsically disordered protein that is highly abundant in
neurons, is closely associated with the onset and progression of Parkinson's disease. We …

Abstract Interleukin 13 receptor alpha 2 (IL13Rα2) is increasingly recognized as a relevant
player in cancer invasion and metastasis. Despite being initially considered a decoy …

The changes in the brain signaling systems play an important role in etiology and
pathogenesis of Type 2 diabetes mellitus (T2DM) and metabolic syndrome (MS), being a …

Endothelial dysfunction is a key feature of cardiovascular disorders associated with obesity
and diabetes. Several studies identified protein tyrosine phosphatase (PTP)-1B, a member …