Tocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic diseases

BB Aggarwal, C Sundaram, S Prasad… - Biochemical …, 2010 - Elsevier
Initially discovered in 1938 as a “fertility factor,” vitamin E now refers to eight different
isoforms that belong to two categories, four saturated analogues (α, β, γ, and δ) called …

Tocotrienols in health and disease: the other half of the natural vitamin E family

CK Sen, S Khanna, S Roy - Molecular aspects of medicine, 2007 - Elsevier
Tocochromanols encompass a group of compounds with vitamin E activity essential for
human nutrition. Structurally, natural vitamin E includes eight chemically distinct molecules …

Cancer-preventive activities of tocopherols and tocotrienols

J Ju, SC Picinich, Z Yang, Y Zhao, N Suh… - …, 2010 - academic.oup.com
The cancer-preventive activity of vitamin E has been studied. Whereas some
epidemiological studies have suggested a protective effect of vitamin E against cancer …

Tocotrienols: The promising analogues of vitamin E for cancer therapeutics

BL Sailo, K Banik, G Padmavathi, M Javadi… - Pharmacological …, 2018 - Elsevier
Despite the significant advancements in the diagnosis and treatment of cancer, it still
remains one of the most fatal diseases in the world due to the lack of sensitive diagnosis …

Vitamin E and cancer: An insight into the anticancer activities of vitamin E isomers and analogs

C Constantinou, A Papas… - International journal of …, 2008 - Wiley Online Library
Current observations in the literature suggest that vitamin E may be a suitable candidate for
the adjuvant treatment of cancer. Even though historically most research focused on α …

Research advancements in palm oil nutrition

CY May, K Nesaretnam - European journal of lipid science and …, 2014 - Wiley Online Library
Palm oil is the major oil produced, with annual world production in excess of 50 million
tonnes. About 85% of global palm oil produced is used in food applications. Over the past …

γ-Tocotrienol inhibits nuclear factor-κB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene …

KS Ahn, G Sethi, K Krishnan, BB Aggarwal - Journal of Biological Chemistry, 2007 - ASBMB
Unlike the tocopherols, the tocotrienols, also members of the vitamin E family, have an
unsaturated isoprenoid side chain. In contrast to extensive studies on tocopherol, very little …

Exploring the potent anticancer activity of essential oils and their bioactive compounds: Mechanisms and prospects for future cancer therapy

F Mohamed Abdoul-Latif, A Ainane… - Pharmaceuticals, 2023 - mdpi.com
Cancer is one of the leading causes of death worldwide, affecting millions of people each
year. Fortunately, the last decades have been marked by considerable advances in the field …

Revisiting the therapeutic potential of tocotrienol

R Ranasinghe, M Mathai, A Zulli - Biofactors, 2022 - Wiley Online Library
The therapeutic potential of the tocotrienol group stems from its nutraceutical properties as a
dietary supplement. It is largely considered to be safe when consumed at low doses for …

Allicin purified from fresh garlic cloves induces apoptosis in colon cancer cells via Nrf2

W Bat-Chen, T Golan, I Peri, Z Ludmer… - Nutrition and …, 2010 - Taylor & Francis
Allicin (diallyl thiosulfinate) is the best-known biologically active component in freshly
crushed garlic extract. We developed a novel, simple method to isolate active allicin, which …