Expanding PET-applications in life sciences with positron-emitters beyond fluorine-18

HH Coenen, J Ermert - Nuclear medicine and biology, 2021 - Elsevier
Abstract Positron-emission-tomography (PET) has become an indispensable diagnostic tool
in modern nuclear medicine. Its outstanding molecular imaging features allow repetitive …

Manganese in PET imaging: Opportunities and challenges

M Brandt, J Cardinale, I Rausch… - Journal of Labelled …, 2019 - Wiley Online Library
Several radionuclides of the transition metal manganese are known and accessible. Three
of them, 51Mn, 52mMn, and 52gMn, are positron emitters that are potentially interesting for …

Production of 52Mn using a semi-automated module

JM Pyles, AVF Massicano, JP Appiah, JL Bartels… - Applied Radiation and …, 2021 - Elsevier
This work focused on the production and purification of the positron emitter 52 Mn (t 1/2= 5.6
d) via the nat Cr (p, n) 52 Mn reaction, using a TR24 cyclotron and a semi-automated system …

Excitation function of 54Fe (p, α) 51Mn from 9.5 MeV to 18 MeV

W Lin, JT Wilkinson, KE Barrett, TE Barnhart, M Gott… - Nuclear Physics A, 2022 - Elsevier
Excitation function of the 54 Fe (p, α) 51 Mn reaction was measured from 9.5 to 18 MeV E 0,
p+ by activating a foil stack of 54 Fe electrodeposited on copper substrates. Residual …

Natural and enriched Cr target development for production of Manganese-52

JM Pyles, JM Omweri, SE Lapi - Scientific Reports, 2023 - nature.com
Abstract 52Mn is a promising PET radiometal with a half-life of 5.6 days and an average
positron energy of 242 keV. Typically, chromium of natural isotope abundance is used as a …

[HTML][HTML] ImmunoPET of the differential expression of CD146 in breast cancer

CA Ferreira, L Kang, C Li, A Kamkaew… - American Journal of …, 2021 - ncbi.nlm.nih.gov
With advancement in antibody engineering, the development and characterization of new
cancer-specific molecular targets are in the forefront of this PET-antibody combination …

Production of a broad palette of positron emitting radioisotopes using a low-energy cyclotron: Towards a new success story in cancer imaging?

R Chakravarty, S Chakraborty - Applied Radiation and Isotopes, 2021 - Elsevier
Over the last several years, positron emission tomography (PET) has matured as an
indispensable component of cancer diagnostics. Owing to the large variability observed …

Metal ion size profoundly affects H 3 glyox chelate chemistry

N Choudhary, KE Barrett, M Kubeil, V Radchenko… - RSC …, 2021 - pubs.rsc.org
The bisoxine hexadentate chelating ligand, H3glyox was investigated for its affinity for Mn2+,
Cu2+ and Lu3+ ions; all three metal ions are relevant with applications in nuclear medicine …

Characterization of actinide resin for separation of 51, 52gMn from bulk target material

KE Barrett, E Aluicio-Sarduy, S Happel… - Nuclear medicine and …, 2021 - Elsevier
We report an extraction chromatography-based method via Actinide Resin for the isolation of
radio-manganese from both natural chromium and isotopically enriched iron targets for …

Non-macrocyclic chelators for metal-based radiopharmaceuticals

N Choudhary - 2021 - open.library.ubc.ca
Radiometals have unique decay properties and half-lives. In order to harness their valuable
properties for use in medicine, we need chelators to tightly bind them and transport them to …