Bone is an extremely dynamic tissue, undergoing continuous remodeling for its whole
lifetime, but its regeneration or augmentation due to bone loss or defects are not always …

The regulatory role of the immune system in maintaining bone homeostasis and restoring its
functionality, when disturbed due to trauma or injury, has become evident in recent years …

It has been confirmed that substantial vascularization is an effective strategy to heal large-
scale bone defects in the field of bone tissue engineering. The local application of …

The disability, mortality and costs due to ionizing radiation (IR)-induced osteoporotic bone
fractures are substantial and no effective therapy exists. Ionizing radiation increases cellular …

Bone fracture healing is a multistep and overlapping process of inflammation, angiogenesis
and osteogenesis. It is initiated by inflammation, causing the release of various cytokines …

Abstract Treatment of large bone defects represents a great challenge in orthopedic and
craniomaxillofacial surgery. Traditional strategies in bone tissue engineering have focused …

Controlled delivery systems play a critical role in the success of bone morphogenetic
proteins (ie, BMP2 and BMP7) for challenged bone repair. Instead of single-drug release …

Bone damage may be triggered by a variety of factors, and the damaged area often requires
a bone graft. Bone tissue engineering can serve as an alternative strategy for repairing large …

Background Hypoxia in the vicinity of bone defects triggers the osteogenic differentiation of
precursor cells and promotes healing. The activation of STAT3 signaling in mesenchymal …

Biomaterials with both excellent osteogenic and angiogenic activities are desirable to repair
massive bone defects. In this study, simvastatin with both osteogenic and angiogenic …