Alignment-free sequence analyses have been applied to problems ranging from whole-
genome phylogeny to the classification of protein families, identification of horizontally …

Genome and metagenome comparisons based on large amounts of next-generation
sequencing (NGS) data pose significant challenges for alignment-based approaches due to …

Background Alignment-free (AF) sequence comparison is attracting persistent interest driven
by data-intensive applications. Hence, many AF procedures have been proposed in recent …

Motivation: Alignment-free methods for sequence comparison are increasingly used for
genome analysis and phylogeny reconstruction; they circumvent various difficulties of …

Motivation: Alignment-based methods for sequence analysis have various limitations if large
datasets are to be analysed. Therefore, alignment-free approaches have become popular in …

We are amidst an ongoing flood of sequence data arising from the application of high-
throughput technologies, and a concomitant fundamental revision in our understanding of …

This paper describes a novel alignment-free distance-based procedure for inferring
phylogenetic trees from genome contig sequences using publicly available bioinformatics …

Motivation Word-based or 'alignment-free'algorithms are increasingly used for phylogeny
reconstruction and genome comparison, since they are much faster than traditional …

The development of rapid, economical genome sequencing has shed new light on the
classification of viruses. As of October 2016, the National Center for Biotechnology …

Alignment-free (AF) approaches have recently been highlighted as alternatives to methods
based on multiple sequence alignment in phylogenetic inference. However, the sensitivity of …