Traumatic spinal cord injury

CS Ahuja, JR Wilson, S Nori, M Kotter… - Nature reviews Disease …, 2017 - nature.com
Traumatic spinal cord injury (SCI) has devastating consequences for the physical, social and
vocational well-being of patients. The demographic of SCIs is shifting such that an …

From basics to clinical: a comprehensive review on spinal cord injury

NA Silva, N Sousa, RL Reis, AJ Salgado - Progress in neurobiology, 2014 - Elsevier
Spinal cord injury (SCI) is a devastating neurological disorder that affects thousands of
individuals each year. Over the past decades an enormous progress has been made in our …

Animal models of spinal cord injury: a systematic review

M Sharif-Alhoseini, M Khormali, M Rezaei, M Safdarian… - Spinal cord, 2017 - nature.com
Study Design: PRISMA-guided systematic review. Objectives: To provide a comprehensive
framework of the current animal models for investigating spinal cord injury (SCI) and …

Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains

DM Basso, LC Fisher, AJ Anderson… - Journal of …, 2006 - liebertpub.com
Genetically engineered mice are used extensively to examine molecular responses to spinal
cord injury (SCI). Inherent strain differences may confound behavioral outcomes; therefore …

CatWalk-assisted gait analysis in the assessment of spinal cord injury

FPT Hamers, GC Koopmans, EAJ Joosten - Journal of neurotrauma, 2006 - liebertpub.com
Gait analysis plays an important role in the assessment of neurological function in many
disease models. In this review, we focus on the newly developed CatWalk system for gait …

Co-delivery of minocycline and paclitaxel from injectable hydrogel for treatment of spinal cord injury

Z Nazemi, MS Nourbakhsh, S Kiani, Y Heydari… - Journal of controlled …, 2020 - Elsevier
Spinal cord injury (SCI) induces pathological and inflammatory responses that create an
inhibitory environment at the site of trauma, resulting in axonal degeneration and functional …

Skin-derived precursors generate myelinating Schwann cells that promote remyelination and functional recovery after contusion spinal cord injury

J Biernaskie, JS Sparling, J Liu… - Journal of …, 2007 - Soc Neuroscience
Transplantation of exogenous cells is one approach to spinal cord repair that could
potentially enhance the growth and myelination of endogenous axons. Here, we asked …

Combination of engineered Schwann cell grafts to secrete neurotrophin and chondroitinase promotes axonal regeneration and locomotion after spinal cord injury

H Kanno, Y Pressman, A Moody, R Berg… - Journal of …, 2014 - Soc Neuroscience
Transplantation of Schwann cells (SCs) is a promising therapeutic strategy for spinal cord
repair. SCs introduced into lesions support axon regeneration, but because these axons do …

The assessment of locomotor function in spinal cord injured rats: the importance of objective analysis of coordination

GC Koopmans, R Deumens, WMM Honig… - Journal of …, 2005 - liebertpub.com
The Basso, Beattie and Bresnahan (BBB) locomotor rating scale is the most widely used
open field test and has been accepted as a valid way to assess locomotor function after …

Rat models of traumatic spinal cord injury to assess motor recovery

SM Onifer, AG Rabchevsky, SW Scheff - ILAR journal, 2007 - academic.oup.com
Devastating motor, sensory, and autonomic dysfunctions render long-term personal
hardships to the survivors of traumatic spinal cord injury (SCI). The suffering also extends to …