One of the most prominent features of tumor cells is uncontrolled cell proliferation caused by
an abnormal cell cycle, and the abnormal expression of cell cycle-related proteins gives …

State-of-the-art next-generation sequencing, transcriptomics, proteomics and other high-
throughput 'omics' technologies enable the efficient generation of large experimental data …

Background Many mutations that contribute to the pathogenesis of acute myeloid leukemia
(AML) are undefined. The relationships between patterns of mutations and epigenetic …

Glucocorticoids are among the most prescribed drugs worldwide for the treatment of
numerous immune and inflammatory disorders. They exert their actions by binding to the …

Background The advantages and utility of microRNAs (miRNAs) as diagnostic and
prognostic cancer markers is at the vanguard in recent years. In this study, we attempted to …

Chronic myeloid leukemia (CML) is a clonal myeloproliferative neoplasm driven by BCR-
ABL1 oncoprotein, which plays a pivotal role in CML pathology, diagnosis, and treatment as …

Background Breast cancer is the most common type of cancer among women, and despite
improved treatments, it remains a major challenge. However, improved mechanistic insight …

MicroRNAs (miRNAs) are important regulators of stem and progenitor cell functions. We
previously reported that miR-142 and miR-150 are upregulated in human breast cancer …

Small non-coding microRNAs (miRNAs) are epigenetic regulators that target specific cellular
mRNA to modulate gene expression patterns and cellular signaling pathways. miRNAs are …

Background Regardless the regulatory function of microRNAs (miRNA), their differential
expression pattern has been used to define miRNA signatures and to disclose disease …