Mechanisms of autophagy–lysosome dysfunction in neurodegenerative diseases
RA Nixon, DC Rubinsztein - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Autophagy is a lysosome-based degradative process used to recycle obsolete cellular
constituents and eliminate damaged organelles and aggregate-prone proteins. Their …
constituents and eliminate damaged organelles and aggregate-prone proteins. Their …
Autophagy in Parkinson's disease
Impaired protein homeostasis and accumulation of damaged or abnormally modified protein
are common disease mechanisms in many neurodegenerative disorders, including …
are common disease mechanisms in many neurodegenerative disorders, including …
Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson's disease
Parkinson's disease (PD) is a complex, chronic and progressive neurodegenerative
disease. While the etiology of PD is likely multifactorial, the protein α-synuclein is a central …
disease. While the etiology of PD is likely multifactorial, the protein α-synuclein is a central …
Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies
Manganese (Mn) is an essential heavy metal. However, Mn's nutritional aspects are
paralleled by its role as a neurotoxicant upon excessive exposure. In this review, we …
paralleled by its role as a neurotoxicant upon excessive exposure. In this review, we …
Activation of β-glucocerebrosidase reduces pathological α-synuclein and restores lysosomal function in Parkinson's patient midbrain neurons
Parkinson's disease (PD) is characterized by the accumulation of α-synuclein (α-syn) within
Lewy body inclusions in the nervous system. There are currently no disease-modifying …
Lewy body inclusions in the nervous system. There are currently no disease-modifying …
At the end of the autophagic road: an emerging understanding of lysosomal functions in autophagy
HM Shen, N Mizushima - Trends in biochemical sciences, 2014 - cell.com
In the past decade, autophagy studies have largely focused on the early stage of autophagy:
the molecular mechanisms leading to autophagosome formation. Recently, however, we …
the molecular mechanisms leading to autophagosome formation. Recently, however, we …
Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration
Parkinson disease (PD) is a progressive neurodegenerative disorder pathologically
characterized by the loss of dopaminergic neurons from the substantia nigra pars compacta …
characterized by the loss of dopaminergic neurons from the substantia nigra pars compacta …
The emerging roles of vacuolar-type ATPase-dependent Lysosomal acidification in neurodegenerative diseases
Background Lysosomes digest extracellular material from the endocytic pathway and
intracellular material from the autophagic pathway. This process is performed by the resident …
intracellular material from the autophagic pathway. This process is performed by the resident …
Lysosomal impairment in Parkinson's disease
Impairment of autophagy‐lysosomal pathways (ALPs) is increasingly regarded as a major
pathogenic event in neurodegenerative diseases, including Parkinson's disease (PD). ALP …
pathogenic event in neurodegenerative diseases, including Parkinson's disease (PD). ALP …
Deficiency of ATP13A2 leads to lysosomal dysfunction, α-synuclein accumulation, and neurotoxicity
M Usenovic, E Tresse, JR Mazzulli… - Journal of …, 2012 - Soc Neuroscience
The autophagy-lysosomal pathway plays an important role in the clearance of long-lived
proteins and dysfunctional organelles. Lysosomal dysfunction has been implicated in …
proteins and dysfunctional organelles. Lysosomal dysfunction has been implicated in …