The incidence of heart valve disease increases significantly with age. Degenerative
abnormalities associated with severe aortic stenosis and mitral and tricuspid regurgitation …

Aims The Society of Thoracic Surgeons (STS) National Database collects detailed clinical
information on patients undergoing adult cardiac, paediatric and congenital cardiac, and …

Background Previous trials have shown that among high-risk patients with aortic stenosis,
survival rates are similar with transcatheter aortic-valve replacement (TAVR) and surgical …

Background The timing and indications for surgical intervention in asymptomatic patients
with severe aortic stenosis remain controversial. Methods In a multicenter trial, we randomly …

Objectives: The purpose of this study was to evaluate the prevalence of aortic stenosis (AS)
in the elderly and to estimate the current and future number of candidates for transcatheter …

Background: Current guidelines generally recommend watchful waiting until symptoms
emerge for aortic valve replacement (AVR) in asymptomatic patients with severe aortic …

Background: Transcatheter aortic valve replacement (TAVR) has revolutionized
management of high-risk patients with severe aortic stenosis. However, survival and the …

Preclinical models of aortic stenosis can induce left ventricular pressure overload and
coarsely control the severity of aortic constriction. However, they do not recapitulate the …

Background: In patients with end-stage renal disease (ESRD), surgical aortic valve
replacement is associated with higher early and late mortality, and adverse outcomes …

Background: Randomized trials support the use of transcatheter aortic valve replacement
(TAVR) for the treatment of aortic stenosis in high-and intermediate-risk patients, but the …