Regulatory mechanisms in T cell receptor signalling
The remarkable T cell receptor (TCR) performs essential functions in the initiation of
intracellular signals required for T cell development, repertoire selection and effector …
intracellular signals required for T cell development, repertoire selection and effector …
The self-obsession of T cells: how TCR signaling thresholds affect fate'decisions' and effector function
KA Hogquist, SC Jameson - Nature immunology, 2014 - nature.com
Self-reactivity was once seen as a potential characteristic of T cells that was eliminated by
clonal selection to protect the host from autoimmune pathology. It is now understood that the …
clonal selection to protect the host from autoimmune pathology. It is now understood that the …
TCR signal strength and T cell development
NRJ Gascoigne, V Rybakin, O Acuto… - Annual review of cell …, 2016 - annualreviews.org
Thymocyte selection involves the positive and negative selection of the repertoire of T cell
receptors (TCRs) such that the organism does not suffer autoimmunity, yet has the benefit of …
receptors (TCRs) such that the organism does not suffer autoimmunity, yet has the benefit of …
The MAMs structure and its role in cell death
N Wang, C Wang, H Zhao, Y He, B Lan, L Sun, Y Gao - Cells, 2021 - mdpi.com
The maintenance of cellular homeostasis involves the participation of multiple organelles.
These organelles are associated in space and time, and either cooperate or antagonize …
These organelles are associated in space and time, and either cooperate or antagonize …
Thymus machinery for T-cell selection
K Kondo, I Ohigashi, Y Takahama - International immunology, 2019 - academic.oup.com
An immunocompetent and self-tolerant pool of naive T cells is formed in the thymus through
the process of repertoire selection. T cells that are potentially capable of responding to …
the process of repertoire selection. T cells that are potentially capable of responding to …
New Insights in the IP3 Receptor and Its Regulation
JB Parys, T Vervliet - Calcium signaling, 2020 - Springer
Abstract The inositol 1, 4, 5-trisphosphate (IP 3) receptor (IP 3 R) is a Ca 2+-release channel
mainly located in the endoplasmic reticulum (ER). Three IP 3 R isoforms are responsible for …
mainly located in the endoplasmic reticulum (ER). Three IP 3 R isoforms are responsible for …
KRAP tethers IP3 receptors to actin and licenses them to evoke cytosolic Ca2+ signals
NB Thillaiappan, HA Smith, P Atakpa-Adaji… - Nature …, 2021 - nature.com
Regulation of IP3 receptors (IP3Rs) by IP3 and Ca2+ allows regenerative Ca2+ signals, the
smallest being Ca2+ puffs, which arise from coordinated openings of a few clustered IP3Rs …
smallest being Ca2+ puffs, which arise from coordinated openings of a few clustered IP3Rs …
Detection of isoforms and genomic alterations by high-throughput full-length single-cell RNA sequencing in ovarian cancer
A Dondi, U Lischetti, F Jacob, F Singer… - Nature …, 2023 - nature.com
Understanding the complex background of cancer requires genotype-phenotype information
in single-cell resolution. Here, we perform long-read single-cell RNA sequencing (scRNA …
in single-cell resolution. Here, we perform long-read single-cell RNA sequencing (scRNA …
T cell receptor signaling for γδT cell development
R Muro, H Takayanagi, T Nitta - Inflammation and Regeneration, 2019 - Springer
T cells are central to the vertebrate immune system. Two distinct types of T cells, αβT and
γδT cells, express different types of T cell antigen receptors (TCRs), αβTCR and γδTCR …
γδT cells, express different types of T cell antigen receptors (TCRs), αβTCR and γδTCR …
Fine-tuning T cell receptor signaling to control T cell development
G Fu, V Rybakin, J Brzostek, W Paster, O Acuto… - Trends in …, 2014 - cell.com
T cell development from immature CD4+ CD8+ double-positive (DP) thymocytes to the
mature CD4 or CD8 single-positive (SP) stage requires proper T cell receptor (TCR) …
mature CD4 or CD8 single-positive (SP) stage requires proper T cell receptor (TCR) …