Inflammation triggered by SARS-CoV-2 and ACE2 augment drives multiple organ failure of severe COVID-19: molecular mechanisms and implications
The widespread occurrence of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) has led to a pandemic of coronavirus disease 2019 (COVID-19). The S spike protein …
CoV-2) has led to a pandemic of coronavirus disease 2019 (COVID-19). The S spike protein …
[HTML][HTML] The ACE2/angiotensin-(1–7)/MAS axis of the renin-angiotensin system: focus on angiotensin-(1–7)
RAS Santos, WO Sampaio, AC Alzamora… - Physiological …, 2017 - journals.physiology.org
The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …
system and hydroelectrolyte balance, with an influence on organs and functions throughout …
ACE2, angiotensin‐(1‐7) and M as receptor axis in inflammation and fibrosis
AC Simões e Silva, KD Silveira… - British journal of …, 2013 - Wiley Online Library
Recent advances have improved our understanding of the renin‐angiotensin system (RAS).
These have included the recognition that angiotensin (A ng)‐(1‐7) is a biologically active …
These have included the recognition that angiotensin (A ng)‐(1‐7) is a biologically active …
ACE inhibition, ACE2 and angiotensin-(1⿿ 7) axis in kidney and cardiac inflammation and fibrosis
ACS e Silva, MM Teixeira - Pharmacological research, 2016 - Elsevier
Abstract The Renin Angiotensin System (RAS) is a pivotal physiological regulator of heart
and kidney homeostasis, but also plays an important role in the pathophysiology of heart …
and kidney homeostasis, but also plays an important role in the pathophysiology of heart …
[HTML][HTML] ACE and ACE2 in kidney disease
S Mizuiri, Y Ohashi - World journal of nephrology, 2015 - ncbi.nlm.nih.gov
Renin angiotensin system (RAS) activation has a significant influence on renal disease
progression. The classical angiotensin-converting enzyme (ACE)-angiotensin II (Ang II)-Ang …
progression. The classical angiotensin-converting enzyme (ACE)-angiotensin II (Ang II)-Ang …
Circulating ACE2 activity is increased in patients with type 1 diabetes and vascular complications
A Soro-Paavonen, D Gordin, C Forsblom… - Journal of …, 2012 - journals.lww.com
Objective: Angiotensin-converting enzyme 2 (ACE2) is a homolog of ACE that
counterbalances the actions of angiotensin (AT) II and promotes vasodilatation. Circulating …
counterbalances the actions of angiotensin (AT) II and promotes vasodilatation. Circulating …
Angiotensin II as a morphogenic cytokine stimulating renal fibrogenesis
C Rüster, G Wolf - Journal of the American Society of Nephrology, 2011 - journals.lww.com
Inhibitors of the renin-angiotensin-aldosterone system attenuate glomerulosclerosis and
interstitial fibrosis. Although the mechanisms underlying their antifibrotic effects are complex …
interstitial fibrosis. Although the mechanisms underlying their antifibrotic effects are complex …
Angiotensin II and the vascular phenotype in hypertension
Hypertension is associated with vascular changes characterised by remodelling, endothelial
dysfunction and hyperreactivity. Cellular processes underlying these perturbations include …
dysfunction and hyperreactivity. Cellular processes underlying these perturbations include …
Roles of hypertension in the rupture of intracranial aneurysms
Y Tada, K Wada, K Shimada, H Makino, EI Liang… - Stroke, 2014 - Am Heart Assoc
Background and Purpose—Systemic hypertension has long been considered a risk factor of
aneurysmal rupture. However, a causal link between systemic hypertension and the …
aneurysmal rupture. However, a causal link between systemic hypertension and the …
Angiotensin 1–7 mediates renoprotection against diabetic nephropathy by reducing oxidative stress, inflammation, and lipotoxicity
The renin-angiotensin system, especially angiotensin II (ANG II), plays a key role in the
development and progression of diabetic nephropathy. ANG 1–7 has counteracting effects …
development and progression of diabetic nephropathy. ANG 1–7 has counteracting effects …