The history of brain drug delivery is reviewed beginning with the first demonstration, in 1914,
that a drug for syphilis, salvarsan, did not enter the brain, due to the presence of a blood …

In an effort to develop novel strategies for delivery of drug candidates arising from rational
drug design and recombinant DNA technology, pharmaceutical scientists have begun to …

Intracranial bleeding is an important cause of brain masses and edema. To study the
pathophysiology of intracerebral hemorrhage, we produced experimental hemorrhages in …

Recent studies indicate that circulating peptides or plasma proteins, such as insulin or
transferrin, or modified proteins, such as cationized albumin, undergo receptor‐mediated or …

l-DOPA is transported across the blood–brain barrier (BBB) by an amino acid transporter,
system L. Recently, it has been demonstrated that system L consists of two subunits, 4F2hc …

Human microvascular endothelial cells were isolated from children's brain and examined for
their morphological characteristics and upregulation of cell adhesion molecules in response …

Capillary endothelial cells of rat epididymal fat pad were isolated and cultured in media
conditioned by bovine aortic endothelial cells and substrata consisting of interstitial or …

Most cases of neonatal bacterial meningitis develop as a result of a hematogenous spread,
but it is not clear how circulating bacteria cross the blood–brain barrier. Attempts to answer …

P-glycoprotein, an active efflux pump of antitumor agents in multidrug-resistant tumor cells,
exists in various normal tissues, including brain capillaries. To study the physiological …

[3H] Cytochalasin B was used as a ligand to identify and characterize the glucose
transporter in cerebral microvessels of the rat and the pig. Specific cytochalasin B binding …