The emergence of drug resistance is a major challenge for oncologists. Resistance can be
categorized as acquired or intrinsic; the alteration of several biological mechanisms …

Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …

According to numerous animal studies, adverse environmental stimuli, including physical,
chemical, and biological factors, can cause low‐grade chronic inflammation and subsequent …

Despite significant progress in clinical management, drug resistance remains a major
obstacle. Recent research based on protein degradation to restrain drug resistance has …

The cellular barriers are major bottlenecks for bioactive compounds entering into cells to
accomplish their biological functions, which limits their biomedical applications …

Dormancy occurs when cells preserve viability but stop proliferating, which is considered an
important cause of tumor relapse, which may occur many years after clinical remission …

Despite considerable advances in the evolution of anticancer therapies, metastasis still
remains the main cause of cancer mortality. Therefore, current strategies for cancer cure …

The development of multidrug resistance in cancer chemotherapy is a major obstacle to the
effective treatment of human malignant tumors. Several epidemiological studies have …

The liver is the most common site of metastases in patients with colorectal cancer. Colorectal
liver metastases (CRLMs) are the result of molecular mechanisms that involve different cells …

Much of the fatality of tumors is linked to the growth of metastases, which can emerge
months to years after apparently successful treatment of primary tumors. Metastases arise …