Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study
H Yu, L Lin, Z Zhang, H Zhang, H Hu - Signal transduction and targeted …, 2020 - nature.com
NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …
activated by various stimuli, transducing a quick but transient transcriptional activity, to …
Tumor necrosis factor receptor‐associated factor 6 (TRAF 6) regulation of development, function, and homeostasis of the immune system
MC Walsh, JE Lee, Y Choi - Immunological reviews, 2015 - Wiley Online Library
Tumor necrosis factor receptor (TNFR)‐associated factor 6 (TRAF 6) is an adapter protein
that mediates a wide array of protein–protein interactions via its TRAF domain and a RING …
that mediates a wide array of protein–protein interactions via its TRAF domain and a RING …
Molecular mechanisms of treg-mediated T cell suppression
A Schmidt, N Oberle, PH Krammer - Frontiers in immunology, 2012 - frontiersin.org
CD4+ CD25highFoxp3+ regulatory T cells (Tregs) can suppress other immune cells and,
thus, are critical mediators of peripheral self-tolerance. On the one hand, Tregs avert …
thus, are critical mediators of peripheral self-tolerance. On the one hand, Tregs avert …
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
CD8 T cells, which have a crucial role in immunity to infection and cancer, are maintained in
constant numbers, but on antigen stimulation undergo a developmental program …
constant numbers, but on antigen stimulation undergo a developmental program …
[HTML][HTML] Gut-liver physiomimetics reveal paradoxical modulation of IBD-related inflammation by short-chain fatty acids
M Trapecar, C Communal, J Velazquez, CA Maass… - Cell systems, 2020 - cell.com
Although the association between the microbiome and IBD and liver diseases is known, the
cause and effect remain elusive. By connecting human microphysiological systems of the …
cause and effect remain elusive. By connecting human microphysiological systems of the …
CARD–BCL-10–MALT1 signalling in protective and pathological immunity
J Ruland, L Hartjes - Nature Reviews Immunology, 2019 - nature.com
Abstract CARD protein–BCL-10–MALT1 (CBM) signalosomes are multiprotein signalling
platforms that control immune and inflammatory pathways in most tissues. After exposure to …
platforms that control immune and inflammatory pathways in most tissues. After exposure to …
Ubiquitination in signaling to and activation of IKK
ZJ Chen - Immunological reviews, 2012 - Wiley Online Library
A role for polyubiquitination in the activation of inhibitor of NF‐κB (IκB) kinase (IKK) through
a proteasome‐independent mechanism was first reported in 1996, but the physiological …
a proteasome‐independent mechanism was first reported in 1996, but the physiological …
Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells
K Aschenbrenner, LM D'Cruz, EH Vollmann… - Nature …, 2007 - nature.com
The parameters specifying whether autoreactive CD4+ thymocytes are deleted (recessive
tolerance) or differentiate into regulatory T cells (dominant tolerance) remain unresolved …
tolerance) or differentiate into regulatory T cells (dominant tolerance) remain unresolved …
[HTML][HTML] TRAF molecules in cell signaling and in human diseases
P Xie - Journal of molecular signaling, 2013 - Springer
The tumor necrosis factor receptor (TNF-R)-associated factor (TRAF) family of intracellular
proteins were originally identified as signaling adaptors that bind directly to the cytoplasmic …
proteins were originally identified as signaling adaptors that bind directly to the cytoplasmic …