Genomic findings in schizophrenia and their implications
There has been substantial progress in understanding the genetics of schizophrenia over
the past 15 years. This has revealed a highly polygenic condition with the majority of the …
the past 15 years. This has revealed a highly polygenic condition with the majority of the …
Polygenic risk scores: An overview from bench to bedside for personalised medicine
B Cross, R Turner, M Pirmohamed - Frontiers in Genetics, 2022 - frontiersin.org
Since the first polygenic risk score (PRS) in 2007, research in this area has progressed
significantly. The increasing number of SNPs that have been identified by large scale GWAS …
significantly. The increasing number of SNPs that have been identified by large scale GWAS …
PGS-Depot: a comprehensive resource for polygenic scores constructed by summary statistics based methods
Polygenic score (PGS) is an important tool for the genetic prediction of complex traits.
However, there are currently no resources providing comprehensive PGSs computed from …
However, there are currently no resources providing comprehensive PGSs computed from …
Impact of selection bias on polygenic risk score estimates in healthcare settings
BackgroundHospital-based biobanks are being increasingly considered as a resource for
translating polygenic risk scores (PRS) into clinical practice. However, since these biobanks …
translating polygenic risk scores (PRS) into clinical practice. However, since these biobanks …
Genetic architecture and socio-environmental risk factors for major depressive disorder in Nepal
BackgroundMajor depressive disorder (MDD) is the leading cause of disability globally, with
moderate heritability and well-established socio-environmental risk factors. Genetic studies …
moderate heritability and well-established socio-environmental risk factors. Genetic studies …
Neuropsychiatric polygenic scores are weak predictors of professional categories
Polygenic scores (PGS) enable the exploration of pleiotropic effects and genomic dissection
of complex traits. Here, in 421,889 individuals with European ancestry from the Million …
of complex traits. Here, in 421,889 individuals with European ancestry from the Million …
Association of healthy lifestyle factors and genetic liability with bipolar disorder: Findings from the UK Biobank
G Li, Q He, M Sun, Z Ma, H Zhao, Y Wang… - Journal of Affective …, 2024 - Elsevier
Background The interplay between genetic and lifestyle factors in the development of
bipolar disorder (BD) remains unclear. Methods A cohort study was carried out on 365,517 …
bipolar disorder (BD) remains unclear. Methods A cohort study was carried out on 365,517 …
Mental illness and cardiovascular health: observational and polygenic score analyses in a population-based cohort study
BackgroundIndividuals with serious mental illness have a markedly shorter life expectancy.
A major contributor to premature death is cardiovascular disease (CVD). We investigated …
A major contributor to premature death is cardiovascular disease (CVD). We investigated …
Genetic analysis of psychosis Biotypes: shared Ancestry-adjusted polygenic risk and unique genomic associations
C Xia, N Alliey-Rodriguez, CA Tamminga… - Molecular …, 2024 - nature.com
Abstract The Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) created
psychosis Biotypes based on neurobiological measurements in a multi-ancestry sample …
psychosis Biotypes based on neurobiological measurements in a multi-ancestry sample …
Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder
Persons diagnosed with schizophrenia (SCZ) or bipolar I disorder (BPI) are at high risk for
self-injurious behavior, suicidal ideation, and suicidal behaviors (SB). Characterizing …
self-injurious behavior, suicidal ideation, and suicidal behaviors (SB). Characterizing …