Gene therapy, as an emerging therapeutic approach, has shown remarkable advantages in
the treatment of some major diseases. With the deepening of genomics research, people …

The cell membrane serves as a barrier against the free entry of foreign substances into the
cell. Limited by factors such as solubility and targeting, it is difficult for some drugs to pass …

The exposure of cancer cells to subtherapeutic drug concentrations results in multidrug
resistance (MDR). The uniqueness of mesoporous silica nanoparticles (MSNPs) with larger …

Accumulation of photosensitisers in photodynamic therapy in healthy tissues is often the
cause of unwanted side effects. Using nanoparticles, improved bioavailability and site …

We postulate that nanoparticles (NPs) for use in therapeutic applications have largely not
realized their clinical potential due to an overall inability to use in vitro results to predict NP …

Therapeutic viral gene delivery is an emerging technology which aims to correct genetic
mutations by introducing new genetic information to cells either to correct a faulty gene or to …

Polyamidoamines (PAMAMs) are a class of dendrimer with monodispersity and controlled
topology, which can deliver biologically active macromolecules (eg, genes and proteins) to …

The immediate release of chemotherapeutics at the target site, along with no premature
release in circulation is always challenging. The purpose of this study was to develop a …

A novel approach to treating cancer has been revealed to be effective cancer vaccination. It
has also been demonstrated that nucleic acid therapies such as mRNA and siRNA are very …

Strategies to overcome toxicity and drug resistance caused by chemotherapeutic drugs for
targeted therapy against hepatocellular carcinoma (HCC) are urgently needed. Previous …