Overview IL-7 is a member of the family of cytokines with four anti-parallel α helixes that bind
Type I cytokine receptors. It is produced by stromal cells and is required for development …

Adoptive cell transfer after host preconditioning by lymphodepletion represents an important
advance in cancer immunotherapy. Here, we describe how a lymphopaenic environment …

Advancing our understanding of mechanisms of immune regulation in allergy, asthma,
autoimmune diseases, tumor development, organ transplantation, and chronic infections …

Memory T cells are critical for long-term immunity against reinfection and require interleukin-
7 (IL-7), but the mechanisms by which IL-7 controls memory T cell survival, particularly …

As acute infections resolve, effector CD8+ T cells differentiate into interleukin-7 receptor lo
(IL-7R lo) short-lived effector cells (SLECs) and IL-7R hi memory precursor effector cells …

A major unanswered question is what distinguishes the majority of activated CD8 T cells that
die after an acute viral infection from the small fraction (5–10%) that survive to become long …

Memory CD8 T cells can be divided into two subsets, central (TCM) and effector (TEM), but
their lineage relationships and their ability to persist and confer protective immunity are not …

The peripheral mature T cell pool is regulated by complex homeostatic mechanisms. Naive
T cells are maintained by interleukin-7 (IL-7) and T cell receptor (TCR) signaling from …

Abstract Interleukin-7 (IL-7) is required for T cell development and for maintaining and
restoring homeostasis of mature T cells. IL-7 is a limiting resource under normal conditions …

T lymphocytes, from their first encounter with their specific antigen as naïve cell until the last
stages of their differentiation, in a replicative state of senescence, go through a series of …