R-loops are non-B DNA structures with intriguing dual consequences for gene expression
and genome stability. In addition to their recognized roles in triggering DNA double-strand …

DNA double-strand breaks require repair or risk corrupting the language of life. To ensure
genome integrity and viability, multiple DNA double-strand break repair pathways function in …

Simple Summary The past decade has seen the development and regulatory approval of a
large number of new treatment options for advanced prostate cancer. Despite this, the two …

DNA damage poses a serious threat to human health and cells therefore continuously
monitor and repair DNA lesions across the genome. Ribosomal DNA is a genomic domain …

Discovery of the CRISPR-Cas (clustered regularly interspaced short palindromic repeat,
CRISPR-associated) system a decade ago has opened new possibilities in the field of …

Genetic manipulations with a robust and predictable outcome are critical to investigate gene
function, as well as for therapeutic genome engineering. For many years, knockdown …

The photolyase family consists of flavoproteins with enzyme activity able to repair ultraviolet
light radiation damage by photoreactivation. DNA damage by the formation of a cyclobutane …

In the quest for cancer treatment modalities with greater effectiveness, the combination of
tumor immunotherapy and nanoparticle-based hyperthermia has emerged as a promising …

Eukaryotic nuclei are constantly being exposed to factors that break or chemically modify the
DNA. Accurate repair of this DNA damage is crucial to prevent DNA mutations and maintain …

Chromosomes are susceptible to damage during their duplication and segregation or when
exposed to genotoxic stresses. Left uncorrected, these lesions can result in genomic …