Cleavable PEGylation: a strategy for overcoming the “PEG dilemma” in efficient drug delivery

Y Fang, J Xue, S Gao, A Lu, D Yang, H Jiang, Y He… - Drug Delivery, 2017 - Taylor & Francis
To prolong the circulation time of drug, PEGylation has been widely used via the enhanced
permeability and retention (EPR) effect, thereby providing new hope for better treatment …

Recent advancements in stimuli responsive drug delivery platforms for active and passive cancer targeting

MA Rahim, N Jan, S Khan, H Shah, A Madni, A Khan… - Cancers, 2021 - mdpi.com
Simple Summary Cancer is one of the leading causes of death globally. Several studies,
efforts and treatment strategies have been put forth for the treatment of different types of …

Polymersome-based drug-delivery strategies for cancer therapeutics

T Anajafi, S Mallik - Therapeutic delivery, 2015 - Taylor & Francis
Polymersomes are stable vesicles prepared from amphiphilic polymers and are more stable
compared with liposomes. Although these nanovesicles have many attractive properties for …

Surface modification of lipid-based nanocarriers for cancer cell-specific drug targeting

CH Kim, SG Lee, MJ Kang, S Lee, YW Choi - Journal of Pharmaceutical …, 2017 - Springer
Targeted drug delivery systems using nanocarriers for anticancer drugs have been
investigated for over several decades. Among the many nanocarrier systems, lipid-based …

Microfluidic preparation and in vitro evaluation of iRGD-functionalized solid lipid nanoparticles for targeted delivery of paclitaxel to tumor cells

I Arduino, Z Liu, RM Iacobazzi, AA Lopedota… - International Journal of …, 2021 - Elsevier
Solid lipid nanoparticles (SLNs) can combine the advantages of different colloidal carriers
and prevent some of their disadvantages. The production of nanoparticles by means of …

Polycations for gene delivery: dilemmas and solutions

J Chen, K Wang, J Wu, H Tian, X Chen - Bioconjugate chemistry, 2018 - ACS Publications
Gene therapy has been a promising strategy for treating numerous gene-associated human
diseases by altering specific gene expressions in pathological cells. Application of nonviral …

Recent advances in endogenous and exogenous stimuli-responsive nanocarriers for drug delivery and therapeutics

H Hatakeyama - Chemical and Pharmaceutical Bulletin, 2017 - jstage.jst.go.jp
Significant progress has been achieved in the development of stimuli-responsive
nanocarriers for drug delivery, diagnosis, and therapy. Various types of triggers are utilized …

Ocular disposition of ciprofloxacin from topical, PEGylated nanostructured lipid carriers: Effect of molecular weight and density of poly (ethylene) glycol

SP Balguri, GR Adelli, KY Janga, P Bhagav… - International journal of …, 2017 - Elsevier
Ciprofloxacin (CIP) is an antibacterial agent prescribed for the treatment of ocular infections.
The objective of the present project is to investigate the effect of surface PEG …

Effects of PEGylated paclitaxel nanocrystals on breast cancer and its lung metastasis

H Zhang, H Hu, H Zhang, W Dai, X Wang, X Wang… - Nanoscale, 2015 - pubs.rsc.org
As an attractive strategy developed rapidly in recent years, nanocrystals are used to deliver
insoluble drugs. PEGylation may further prolong the circulation time of nanoparticles and …

Novel targets for paclitaxel nano formulations: hopes and hypes in triple negative breast cancer

AK Bakrania, BC Variya, SS Patel - Pharmacological Research, 2016 - Elsevier
Triple negative breast cancer is defined as one of the utmost prevailing breast cancers
worldwide, possessing an inadequate prognosis and treatment option limited to …