Laser ablation–inductively coupled plasma–mass spectrometry imaging in biology

PA Doble, RG de Vega, DP Bishop, DJ Hare… - Chemical …, 2021 - ACS Publications
Elemental imaging gives insight into the fundamental chemical makeup of living organisms.
Every cell on Earth is comprised of a complex and dynamic mixture of the chemical elements …

Recent applications of laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) for biological sample analysis: a follow-up review

D Pozebon, GL Scheffler, VL Dressler - Journal of Analytical Atomic …, 2017 - pubs.rsc.org
Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) is a feasible
technique to obtain either quantitative elemental data or spatially resolved imaging/mapping …

Exploring ion suppression in mass spectrometry imaging of a heterogeneous tissue

AJ Taylor, A Dexter, J Bunch - Analytical chemistry, 2018 - ACS Publications
In this study we have explored several aspects of regional analyte suppression in mass
spectrometry imaging (MSI) of a heterogeneous sample, transverse cryosections of mouse …

Calibration strategies for laser ablation ICP-MS in biological studies: A review

H Pan, L Feng, Y Lu, Y Han, J Xiong, H Li - TrAC Trends in Analytical …, 2022 - Elsevier
Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) has attracted
attentions for its high sensitivity and sufficient spatial resolution in the in-situ analysis and …

Imaging metals in biology: balancing sensitivity, selectivity and spatial resolution

DJ Hare, EJ New, MD de Jonge… - Chemical Society Reviews, 2015 - pubs.rsc.org
Metal biochemistry drives a diverse range of cellular processes associated with
development, health and disease. Determining metal distribution, concentration and flux …

Single-cell analysis by use of ICP-MS

S Theiner, K Loehr, G Koellensperger… - Journal of Analytical …, 2020 - pubs.rsc.org
This tutorial review article is highlighting the fundamentals, instrumentation, and most recent
trends of single-cell analysis by use of inductively coupled plasma-mass spectrometry (ICP …

Gelatin gels as multi-element calibration standards in LA-ICP-MS bioimaging: fabrication of homogeneous standards and microhomogeneity testing

M Šala, VS Šelih, JT van Elteren - Analyst, 2017 - pubs.rsc.org
Highly homogeneous multi-element gelatin calibration standards were fabricated for
quantitative LA-ICP-MS bioimaging. Heterogeneity issues caused by the so-called “coffee …

Expanding the boundaries of atomic spectroscopy at the single-cell level: critical review of SP-ICP-MS, LIBS and LA-ICP-MS advances for the elemental analysis of …

C Davison, D Beste, M Bailey… - Analytical and bioanalytical …, 2023 - Springer
Metals have a fundamental role in microbiology, and accurate methods are needed for their
identification and quantification. The inability to assess cellular heterogeneity is considered …

[HTML][HTML] Calibration approaches in laser ablation inductively coupled plasma mass spectrometry for bioimaging applications

K Mervič, M Šala, S Theiner - TrAC Trends in Analytical Chemistry, 2024 - Elsevier
Laser ablation (LA) in combination with inductively coupled plasma mass spectrometry (ICP-
MS) is a technically advanced micro-analytical method for direct sampling of solid materials …

High-speed, high-resolution, multielemental LA-ICP-TOFMS imaging: Part II. Critical evaluation of quantitative three-dimensional imaging of major, minor, and trace …

M Burger, A Gundlach-Graham, S Allner… - Analytical …, 2015 - ACS Publications
Here we describe the capabilities of laser-ablation coupled to inductively coupled plasma
time-of-flight mass spectrometry (LA-ICP-TOFMS) for high-speed, high-resolution …