Different metabolic profiles as well as comorbidities are common in people with Down
Syndrome (DS). Therefore it is relevant to know whether micronutrient levels in people with …

Single nucleotide polymorphisms (SNPs) are important biomolecular markers in health and
disease. Down syndrome, or Trisomy 21, is the most frequently occurring chromosomal …

Objective: To examine the associations of methionine synthase (MTR), methionine synthase
reductase (MTRR), and methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms …

Folate and other B vitamins are essential co-factors of one-carbon metabolism, and genetic
variants, such as polymorphisms, can alter the metabolism. Furthermore, the adoption of …

Objectives Recently, elevated homocysteine was reported to be associated with frailty in
cross-sectional studies. However, whether homocysteine is causally associated with frailty is …

Choline and betaine are essential nutrients involved in one-carbon metabolism and have
been hypothesised to affect breast cancer risk. Functional polymorphisms in genes …

Methionine synthase (MTR) is required for the conversion of homocysteine (hcy) to
methionine in the one-carbon metabolic pathway. Previous studies investigating a common …

Aims: Down syndrome (DS) is the most common chromosomal abnormality. Many studies
have assessed the association between maternal gene polymorphisms involved in folate …

Previous studies have focused on the association between polymorphisms of the genes
involved in folate metabolism and Down syndrome (DS); however, the results remain …

Background: Down syndrome (DS) results from the presence and expression of three copies
of the genes located on chromosome 21. Studies have shown that, in addition to …