ZAP is an antiviral protein that binds to and depletes viral RNA, which is often distinguished
from vertebrate host RNA by its elevated CpG content. Two ZAP cofactors, TRIM25 and …

Suppressor of cytokine signaling 2 (SOCS2), an E3 ubiquitin ligase, regulates the JAK/STAT
signaling pathway, essential for cytokine signaling and immune responses. Its dysregulation …

The cytokine TNF can trigger highly proinflammatory RIPK1-dependent cell death. Here, we
show that the two adapter proteins, TANK and AZI2, suppress TNF-induced cell death by …

Targeting neuronal precursor cell-expressed developmentally down-regulated 4 (NEDD4)
offers a promising strategy for cardiovascular therapies. NEDD4, a ubiquitin ligase enzyme …

Atrazine (ATR) is a widespread environmental herbicide that seriously affects agricultural
work and human safety. Melatonin (MLT) as an endogenous neuroendocrine hormone is …

ABSTRACT Enteroviral 3C protease (3Cpro) is an essential enzyme for viral replication and
is responsible for combating the host anti-viral immune response by targeting cellular …

The disruption of nerve parenchyma and axonal networks triggered by spinal cord injury
(SCI) can initiate a cascade of events associated with secondary injury. Toll‐like receptors …

Zinc finger antiviral protein (ZAP) binds CpG dinucleotides in viral RNA and targets them for
decay. ZAP interacts with several cofactors to form the ZAP antiviral system, including …

SOCS2, an E3 ubiquitin ligase, regulates the JAK/STAT signaling pathway, essential for
cytokine signaling and immune responses. Its dysregulation contributes to cardiovascular …

Osteoporosis is a common bone metabolism disease, with a complex pathogenesis that has
not been fully elucidated yet. In recent years, studies have found that the Toll-like 4 receptor …