[HTML][HTML] Implementing differentially pigmented skin models for predicting drug response variability across human ancestries

S Zaaijer, SC Groen - Human Genomics, 2024 - Springer
Persistent racial disparities in health outcomes have catalyzed legislative reforms and
heightened scientific focus recently. However, despite the well-documented properties of …

A compendium for novel marker-based breeding strategies in eggplant

L Gaccione, M Martina, L Barchi, E Portis - Plants, 2023 - mdpi.com
The worldwide production of eggplant is estimated at about 58 Mt, with China, India and
Egypt being the major producing countries. Breeding efforts in the species have mainly …

Analysis of structural variation among inbred mouse strains

A Arslan, Z Fang, M Wang, Y Tan, Z Cheng, X Chen… - BMC genomics, 2023 - Springer
Background 'Long read'sequencing methods have been used to identify previously
uncharacterized structural variants that cause human genetic diseases. Therefore, we …

Neuron Navigator 1 (Nav1) regulates the response to cocaine in mice

JR Bagley, Y Tan, W Zhu, Z Cheng, S Takeda… - Communications …, 2023 - nature.com
Genetic variation accounts for much of the risk for developing a substance use disorder, but
the underlying genetic factors and their genetic effector mechanisms are mostly unknown …

An automated multi-modal graph-based pipeline for mouse genetic discovery

Z Fang, G Peltz - Bioinformatics, 2022 - academic.oup.com
Motivation Our ability to identify causative genetic factors for mouse genetic models of
human diseases and biomedical traits has been limited by the difficulties associated with …

Genome-wide association study of drought tolerance traits in sugar beet germplasms at the seedling stage

W Li, M Lin, J Li, D Liu, W Tan, X Yin, Y Zhai… - Frontiers in …, 2023 - frontiersin.org
Introduction: Sugar beets are an important crop for global sugar production. Intense drought
and the increasing lack of water resources pose a great threat to sugar beet cultivation. It is a …

Twenty-first century mouse genetics is again at an inflection point

Z Fang, G Peltz - Lab Animal, 2024 - nature.com
The laboratory mouse has been the premier model organism for biomedical research owing
to the availability of multiple well-characterized inbred strains, its mammalian physiology …

High throughput computational mouse genetic analysis

A Arslan, Y Guan, Z Fang, X Chen, R Donaldson… - BioRxiv, 2020 - biorxiv.org
Background Genetic factors affecting multiple biomedical traits in mice have been identified
when GWAS data, which measured responses in panels of inbred mouse strains, was …

What have we learned (or expect to) from analysis of murine genetic models related to substance use disorders?

G Peltz, Y Tan - Frontiers in Psychiatry, 2022 - frontiersin.org
The tremendous public health problem created by substance use disorders (SUDs) presents
a major opportunity for mouse genetics. Inbred mouse strains exhibit substantial and …

Analysis of structural variation among inbred mouse strains identifies genetic factors for autism-related traits

A Arslan, Z Fang, M Wang, Z Cheng, B Yoo… - BioRxiv, 2021 - biorxiv.org
The genomes of six inbred strains were analyzed using long read (LR) sequencing. The
results revealed that structural variants (SV) were very abundant within the genome of …