Abstract The International Mouse Phenotyping Consortium (IMPC) continues to expand the
catalogue of mammalian gene function by conducting genome and phenome-wide …

Sonic hedgehog signaling regulates processes of embryonic development across multiple
tissues, yet factors regulating context-specific Shh signaling remain poorly understood …

In this work, we report the use of iodine-contrast microCT to perform high-throughput 3D
morphological analysis of mouse embryos and neonates between embryonic day 8.5 to …

The small EDRK-rich factor 2 (SERF2) is a highly conserved protein that modifies amyloid
fibre assembly in vitro and promotes protein misfolding. However, the role of SERF2 in …

Mouse studies continue to help elaborate upon the genetic landscape of mammalian
disease and the underlying molecular mechanisms. Here, we have investigated an Embigin …

Advanced 3D imaging modalities, such as micro-computed tomography (micro-CT), have
been incorporated into the high-throughput embryo pipeline of the International Mouse …

Anorectal malformations (ARMs) are relatively common congenital abnormalities, but their
pathogenesis is poorly understood. Previous gene knockout studies indicated that the …

ARL15, a small GTPase protein, was linked to metabolic traits in association studies. We
aimed to test the Arl15 gene as a functional candidate for metabolic traits in the mouse …

The IMPC/KOMP program provides the opportunity to screen mice harboring well defined
gene-inactivation mutations in a uniform genetic background. The program performs a …

Gyration is a feature of many mammalian neocortices; though the developmental
mechanisms that produce cortical gyri are poorly understood. Defects in gyrification can lead …