Hirschsprung disease

L Montalva, LS Cheng, R Kapur, JC Langer… - Nature Reviews …, 2023 - nature.com
Hirschsprung disease (HSCR) is a rare congenital intestinal disease that occurs in 1 in
5,000 live births. HSCR is characterized by the absence of ganglion cells in the myenteric …

[HTML][HTML] The etiology of congenital diaphragmatic hernia: the retinoid hypothesis 20 years later

JFG Rivas, RD Clugston - Pediatric Research, 2024 - nature.com
Congenital diaphragmatic hernia (CDH) is a severe birth defect and a major cause of
neonatal respiratory distress. Impacting~ 2–3 in 10,000 births, CDH is associated with a high …

[HTML][HTML] A strategy to reduce the carbon footprint of clinical trials

F Adshead, RAS Salman, S Aumonier, M Collins… - The Lancet, 2021 - thelancet.com
5 Global PaedSurg Research Collaboration. Mortality from gastrointestinal congenital
anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a …

Congenital diaphragmatic hernia

A Zani, WK Chung, J Deprest, MT Harting… - Nature Reviews …, 2022 - nature.com
Congenital diaphragmatic hernia (CDH) is a rare birth defect characterized by incomplete
closure of the diaphragm and herniation of fetal abdominal organs into the chest that results …

[HTML][HTML] Establishment of a condition-specific quality-of-life questionnaire for children born with esophageal atresia aged 2–7 across 14 countries

International EA-QoL Group - Frontiers in Pediatrics, 2023 - frontiersin.org
Background Esophageal atresia (EA) is a rare congenital anomaly characterized by a
discontinuity of the esophagus. Following surgical repair, survival rates have improved …

[HTML][HTML] Survival of children with rare structural congenital anomalies: a multi-registry cohort study

A Coi, M Santoro, A Pierini, J Rankin… - Orphanet journal of rare …, 2022 - Springer
Background Congenital anomalies are the leading cause of perinatal, neonatal and infant
mortality in developed countries. Large long-term follow-up studies investigating survival …

Surgical research—comic opera no more

J Bagenal, N Lee, AO Ademuyiwa, D Nepogodiev… - The Lancet, 2023 - thelancet.com
“A comic opera performance” was how Richard Horton, Editor-in-Chief of The Lancet,
described surgical research in 1996 when he quoted the medical statistician Major …

[HTML][HTML] Neonatal surgical morbidity and mortality at a single tertiary center in a low-and middle-income country: a retrospective study of clinical outcomes

MS Hasan, N Islam, AR Mitul - Frontiers in Surgery, 2022 - frontiersin.org
The limitations in the LMICs, both logistic & financial are the greatest challenges deferring
the improvement in neonatal & pediatric surgical outcomes needs to be addressed with …

Hirschsprung's disease in low-and middle-income countries

S Trinidad, P Kayima, V Kotecha, A Massenga… - Seminars in pediatric …, 2022 - Elsevier
Hirschsprung's disease (HD) is one of the most common causes of pediatric bowel
obstruction in low-and middle-income countries (LMICs). This paper describes the unique …

[HTML][HTML] Prevalence, pattern, and outcome of congenital anomalies admitted to a neonatal unit in a low-income country—a ten-year retrospective study

B Anane-Fenin, DA Opoku, L Chauke - Maternal and Child Health Journal, 2023 - Springer
Objective The incidence of congenital abnormalities is highest in low-and-middle-income
countries. However, the prevalence, spectrum, trends of neonatal congenital anomalies and …