Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing

B Boland, WH Yu, O Corti, B Mollereau… - Nature reviews Drug …, 2018 - nature.com
Neurodegenerative disorders of ageing (NDAs) such as Alzheimer disease, Parkinson
disease, frontotemporal dementia, Huntington disease and amyotrophic lateral sclerosis …

Nanoparticle-based drug delivery systems to overcome gastric cancer drug resistance

K Nejati, M Rastegar, F Fathi, M Dadashpour… - Journal of Drug Delivery …, 2022 - Elsevier
Gastric cancer (GC) results from deregulated cell growth in the stomach. Despite significant
efforts and recent advancements in the treatment of gastric cancer, it remains a life …

Size-dependent effects of polystyrene nanoplastics on autophagy response in human umbilical vein endothelial cells

YY Lu, H Li, H Ren, X Zhang, F Huang, D Zhang… - Journal of Hazardous …, 2022 - Elsevier
Ubiquitous nanoplastics (NPs) increase exposure risks to humans through the food chain
and/or other ways. However, huge knowledge gaps exist regarding the fate and adverse …

Pro-death or pro-survival: contrasting paradigms on nanomaterial-induced autophagy and exploitations for cancer therapy

Y Zhang, L Zhang, J Gao, L Wen - Accounts of Chemical Research, 2019 - ACS Publications
Conspectus Autophagy is a critical lysosome-mediated cellular degradation process for the
clearance of damaged organelles, obsolete proteins, and invading pathogens and plays …

Photodynamic N-TiO2 Nanoparticle Treatment Induces Controlled ROS-mediated Autophagy and Terminal Differentiation of Leukemia Cells

MA Moosavi, M Sharifi, SM Ghafary… - Scientific reports, 2016 - nature.com
In this study, we used nitrogen-doped titanium dioxide (N-TiO2) NPs in conjugation with
visible light, and show that both reactive oxygen species (ROS) and autophagy are induced …

Differential effects of N‐TiO2 nanoparticle and its photo‐activated form on autophagy and necroptosis in human melanoma A375 cells

Z Mohammadalipour, M Rahmati… - Journal of cellular …, 2020 - Wiley Online Library
The manipulation of autophagy provides a new opportunity for highly effective anticancer
therapies. Recently, we showed that photodynamic therapy (PDT) with nitrogen‐doped …

Perturbation of autophagy: an intrinsic toxicity mechanism of nanoparticles

X Zhou, W Jin, H Sun, C Li, J Jia - Science of The Total Environment, 2022 - Elsevier
Nanoparticles (NPs) have been widely used for various purposes due to their unique
physicochemical properties. Such widespread applications greatly increase the possibility of …

TiO2 nanoparticles enhance the chemotherapeutic effects of 5-fluorouracil in human AGS gastric cancer cells via autophagy blockade

S Azimee, M Rahmati, H Fahimi, MA Moosavi - Life sciences, 2020 - Elsevier
Abstract Aims Nanoparticles (NPs)-based drugs have been recently introduced to improve
the efficacy of current therapeutic strategies for the treatment of cancer; however, the …

The role of hypoxia-inducible factor-1α in zinc oxide nanoparticle-induced nephrotoxicity in vitro and in vivo

YF Lin, IJ Chiu, FY Cheng, YH Lee, YJ Wang… - Particle and fibre …, 2015 - Springer
Abstract Background Zinc oxide nanoparticles (ZnO NPs) are used in an increasing number
of products, including rubber manufacture, cosmetics, pigments, food additives, medicine …

Autophagy regulation by inorganic, organic, and organic/inorganic hybrid nanoparticles: organelle damage, regulation factors, and potential pathways

D Qiao, T Zhang, M Tang - Journal of Biochemical and …, 2023 - Wiley Online Library
The rapid development of nanotechnology requires a more thorough understanding of the
potential health effects caused by nanoparticles (NPs). As a programmed cell death …