Transglutaminase regulation of cell function
RL Eckert, MT Kaartinen, M Nurminskaya… - Physiological …, 2014 - journals.physiology.org
Transglutaminases (TGs) are multifunctional proteins having enzymatic and scaffolding
functions that participate in regulation of cell fate in a wide range of cellular systems and are …
functions that participate in regulation of cell fate in a wide range of cellular systems and are …
Transglutaminases and disease: lessons from genetically engineered mouse models and inherited disorders
SE Iismaa, BM Mearns, L Lorand… - Physiological …, 2009 - journals.physiology.org
The human transglutaminase (TG) family consists of a structural protein, protein 4.2, that
lacks catalytic activity, and eight zymogens/enzymes, designated factor XIII-A (FXIII-A) and …
lacks catalytic activity, and eight zymogens/enzymes, designated factor XIII-A (FXIII-A) and …
Cellular functions of tissue transglutaminase
MV Nurminskaya, AM Belkin - International review of cell and molecular …, 2012 - Elsevier
Transglutaminase 2 (TG2 or tissue transglutaminase) is a highly complex multifunctional
protein that acts as transglutaminase, GTPase/ATPase, protein disulfide isomerase, and …
protein that acts as transglutaminase, GTPase/ATPase, protein disulfide isomerase, and …
[HTML][HTML] Transglutaminase 2: a molecular Swiss army knife
S Gundemir, G Colak, J Tucholski… - Biochimica et Biophysica …, 2012 - Elsevier
Transglutaminase 2 (TG2) is the most widely distributed member of the transglutaminase
family with almost all cell types in the body expressing TG2 to varying extents. In addition to …
family with almost all cell types in the body expressing TG2 to varying extents. In addition to …
Transglutaminase 2 inhibitors and their therapeutic role in disease states
Transglutaminase 2 (TG2) is a multi-domain, multi-functional enzyme that post-
translationally modifies proteins by catalyzing the formation of intermolecular isopeptide …
translationally modifies proteins by catalyzing the formation of intermolecular isopeptide …
Extracellular transglutaminase 2 is catalytically inactive, but is transiently activated upon tissue injury
Transglutaminase 2 (TG2) is a multifunctional mammalian protein with transamidase and
signaling properties. Using selective TG2 inhibitors and tagged nucleophilic amine …
signaling properties. Using selective TG2 inhibitors and tagged nucleophilic amine …
Transglutaminase 2: a multi-functional protein in multiple subcellular compartments
D Park, SS Choi, KS Ha - Amino acids, 2010 - Springer
Abstract Transglutaminase 2 (TG2) is a multifunctional protein that can function as a
transglutaminase, G protein, kinase, protein disulfide isomerase, and as an adaptor protein …
transglutaminase, G protein, kinase, protein disulfide isomerase, and as an adaptor protein …
Inhibitors of tissue transglutaminase
JW Keillor, KYP Apperley, A Akbar - Trends in pharmacological sciences, 2015 - cell.com
Tissue transglutaminase (TG2) catalyzes the cross-linking of proteins by the formation of
isopeptide bonds between glutamine (Gln) and lysine (Lys) side chains. Although TG2 is …
isopeptide bonds between glutamine (Gln) and lysine (Lys) side chains. Although TG2 is …
Transglutaminase 2 is needed for the formation of an efficient phagocyte portal in macrophages engulfing apoptotic cells
Abstract Transglutaminase 2 (TG2), a protein cross-linking enzyme with many additional
biological functions, acts as coreceptor for integrin β 3. We have previously shown that …
biological functions, acts as coreceptor for integrin β 3. We have previously shown that …
Transglutaminase is a tumor cell and cancer stem cell survival factor
RL Eckert, ML Fisher, D Grun, G Adhikary… - Molecular …, 2015 - Wiley Online Library
Recent studies indicate that cancer cells express elevated levels of type II transglutaminase
(TG2), and that expression is further highly enriched in cancer stem cells derived from these …
(TG2), and that expression is further highly enriched in cancer stem cells derived from these …